N-ethyl-2,3,5,6-tetrafluoro-4-methoxybenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-ethyl-2,3,5,6-tetrafluoro-4-methoxybenzamide
• 化学式: C₁₀H₉F₄NO₂
• 分子量: 251.18
• InChiKey: WRHPJLWFAQWXNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Activity-based probe compounds, compositions, and methods of use
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：US10869936B2

  公开（公告）日：2020-12-22

  Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.

  提供了用于标记半胱氨酸蛋白酶的基于活性的探针化合物。这些化合物通过特定的靶向元件靶向蛋白酶。化合物还包括可检测元素，如荧光标签、放射性标签或螯合剂。在某些情况下，化合物还包括一种淬灭元素，在与蛋白酶反应时释放出来。此外，还提供了包含这些化合物的组合物和使用这些化合物的方法，例如标记动物体内的蛋白酶和观察动物体内的肿瘤。
• METHODS AND COMPOSITIONS FOR TREATING ATRIAL FIBRILLATION
  申请人：The Regents of The University of Michigan

  公开号：US20140241988A1

  公开（公告）日：2014-08-28

  The present invention relates to compositions and methods for the prevention and treatment of atrial fibrillation. In particular, the present invention provides therapeutic agents for the treatment and prevention of persistent and permanent atrial fibrillation and prevention of progression of atrial fibrillation to permanent atrial fibrillation.
• ACTIVITY-BASED PROBE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：US20200038524A1

  公开（公告）日：2020-02-06

  Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.