(5R,8S)-8-methyl-3-oxa-1-azaspiro[4.4]nonan-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (5R,8S)-8-methyl-3-oxa-1-azaspiro[4.4]nonan-2-one
• 化学式: C₈H₁₃NO₂
• 分子量: 155.19
• InChiKey: HZVZTVWSUZXVSZ-POYBYMJQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] BICYCLIC COMPOUNDS<br/>[FR] COMPOSÉS BICYCLIQUES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014130752A2

  公开（公告）日：2014-08-28

  Disclosed are compounds of Formula (I) and/or a salt thereof; wherein R is -OH or -OP(O)(OH)2. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.