[(2-Hydroxybenzoyl)amino] octanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(2-Hydroxybenzoyl)amino] octanoate
• 英文别名: [(2-hydroxybenzoyl)amino] octanoate
• 化学式: C₁₅H₂₁NO₄
• 分子量: 279.33
• InChiKey: XIGPDIAJISVNBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• FORMULATIONS FOR ORAL ADMINISTRATION OF ACTIVE AGENTS
  申请人：Entera Bio Ltd.

  公开号：EP3500291A1

  公开（公告）日：2019-06-26
• METHOD OF TREATING CANCER
  申请人：Intensity Therapeutics, Inc.

  公开号：US20140248211A1

  公开（公告）日：2014-09-04

  The invention provides a method for treating cancer using a coadministration strategy that combines local codelivery of a therapeutic agent and an intracellular penetration enhancing agent, and optionally in further combination with local administration of an immunotherapeutic agent, such as a cancer vaccine or NKT agonist. The invention also provides a method for treating cancer using an intracellular penetration enhancing agent. The methods of the invention aim to substantially kill and/or destroy the target tumor cells, as well as those cancerous cells that have metastasized to other parts of the body.
• US9351997B2
  申请人：——

  公开号：US9351997B2

  公开（公告）日：2016-05-31
• [EN] FORMULATIONS FOR ORAL ADMINISTRATION OF ACTIVE AGENTS<br/>[FR] FORMULATIONS POUR L'ADMINISTRATION PAR VOIE ORALE D'AGENTS ACTIFS
  申请人：ENTERA BIO LTD

  公开号：WO2018033927A1

  公开（公告）日：2018-02-22

  Pharmaceutical compositions comprising a therapeutically active agent and an absorption enhancer such as NAC, NAD, 5-CNAC, 4-MOAC, 4-CNAB or a salt thereof, for use in the treatment of a condition treatable by said therapeutically active agent, are provided. The compositions are for concomitant oral administration of two or more of the unit dosage form, which form together a therapeutically effective amount of the therapeutically active agent and an effective amount of the absorption enhancer. Multi-dose compositions comprising the two or more of the unit dosage form are also provided.