2-(4-Chloro-3-fluorophenyl)-2-(3-chlorophenyl)acetaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-Chloro-3-fluorophenyl)-2-(3-chlorophenyl)acetaldehyde
• 英文别名: 2-(4-chloro-3-fluorophenyl)-2-(3-chlorophenyl)acetaldehyde
• 化学式: C₁₄H₉Cl₂FO
• 分子量: 283.1
• InChiKey: VCDMEHFCLNDPQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• A BENZOIC ACID DERIVATIVE MDM2 INHIBITOR FOR THE TREATMENT OF CANCER
  申请人：Amgen Inc.

  公开号：EP2961735A1

  公开（公告）日：2016-01-06
• COMBINATION THERAPY INCLUDING AN MDM2 INHIBITOR AND ONE OR MORE ADDITIONAL PHARMACEUTICALLY ACTIVE AGENTS FOR THE TREATMENT OF CANCERS
  申请人：Amgen Inc.

  公开号：EP3068393A2

  公开（公告）日：2016-09-21
• [EN] A BENZOIC ACID DERIVATIVE MDM2 INHIBITOR FOR THE TREATMENT OF CANCER<br/>[FR] INHIBITEUR MDM2 DÉRIVÉ DE L'ACIDE BENZOÏQUE POUR LE TRAITEMENT DU CANCER
  申请人：AMGEN INC

  公开号：WO2014134201A1

  公开（公告）日：2014-09-04

  The present invention provides a MDM2 inhibitor compound, or a pharmaceutically acceptable salt thereof, which compound is useful as a therapeutic agent, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contains the MDM2 inhibitor.
• [EN] COMBINATION THERAPY INCLUDING AN MDM2 INHIBITOR AND ONE OR MORE ADDITIONAL PHARMACEUTICALLY ACTIVE AGENTS FOR THE TREATMENT OF CANCERS<br/>[FR] POLYTHÉRAPIE COMPRENANT UN INHIBITEUR DE MDM2 ET UN OU PLUSIEURS PRINCIPES PHARMACEUTIQUEMENT ACTIFS SUPPLÉMENTAIRES POUR LE TRAITEMENT DE CANCERS
  申请人：AMGEN INC

  公开号：WO2015070224A2

  公开（公告）日：2015-05-14

  The present invention provides combination therapy that includes an MDM2 inhibitor and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.