N-[2-[2-[2-(3-acetamido-5-phenyl-3H-1,2,4-thiadiazol-2-yl)ethylsulfanyl]ethyl]-5-phenyl-3H-1,2,4-thiadiazol-3-yl]acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-[2-[2-(3-acetamido-5-phenyl-3H-1,2,4-thiadiazol-2-yl)ethylsulfanyl]ethyl]-5-phenyl-3H-1,2,4-thiadiazol-3-yl]acetamide
• 化学式: C₂₄H₂₈N₆O₂S₃
• 分子量: 528.7
• InChiKey: AUNYXUWEGUBQOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  165
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] LABELED GLUTAMINASE PROTEINS, ISOLATED GLUTAMINASE PROTEIN MUTANTS, METHODS OF USE, AND KIT<br/>[FR] PROTÉINES GLUTAMINASES MARQUÉES, MUTANTS ISOLÉS DE LA PROTÉINE GLUTAMINASE, PROCÉDÉS D'UTILISATION ET KIT
  申请人：UNIV CORNELL

  公开号：WO2014134329A1

  公开（公告）日：2014-09-04

  The present invention relates to a labeled glutaminase (GLS) protein comprising a GLS protein and a fluorescent reporter group attached to the GLS protein, wherein the fluorescent reporter group is attached to the GLS protein within the glutaminase domain pfam04960 of GLS. The present invention also relates to isolated glutaminase protein mutants. Also disclosed is a method of screening for compounds that allosterically bind to a glutaminase protein. The present invention also relates to a method of identifying compounds that inhibit or stabilize tetramer formation of glutaminase protein. The present invention further relates to a screening kit for compounds that inhibit or stabilize tetramer formation.