N-[2-(hydrazinecarbonyl)phenyl]thiophene-2-sulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-(hydrazinecarbonyl)phenyl]thiophene-2-sulfonamide
• 化学式: C₁₁H₁₁N₃O₃S₂
• mdl: MFCD03147338
• 分子量: 297.4
• InChiKey: RVIPJODBXNVCTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  138
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATIING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS<br/>[FR] PETITES MOLÉCULES POUR LA MODULATION DE MCL-1 ET PROCÉDÉS DE MODULATION DE LA MORT CELLULAIRE, LA DIVISION CELLULAIRE, LA DIFFÉRENCIATION CELLULAIRE ET PROCÉDÉS DE TRAITEMENT DE TROUBLES
  申请人：DANA FARBER CANCER INST INC

  公开号：WO2011094708A2

  公开（公告）日：2011-08-04

  This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.