1-Methyl-5-propan-2-ylpyrazolidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-Methyl-5-propan-2-ylpyrazolidine
• 英文别名: 1-methyl-5-propan-2-ylpyrazolidine
• 化学式: C₇H₁₆N₂
• 分子量: 128.22
• InChiKey: CTHNJRSBCHICSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] 4-AMINOFURAN-2 (5H) ONE DERIVATIVES, PREPARATION METHODS AND APPLICATIONS THEREOF<br/>[FR] DÉRIVÉS DE 4-AMINOFURAN-2(5H)ONE, LEURS PROCÉDÉS DE PRÉPARATION ET LEURS APPLICATIONS
  申请人：DONGGUAN HEC PESTICIDES R&D CO LTD

  公开号：WO2020228687A1

  公开（公告）日：2020-11-19

  Provided are a 4-aminofuran-2 (5H) ketone derivative having formula (I) or a stereoisomer, an N-oxide, and a salt thereof, and preparation methods of 4-aminofuran-2 (5H) ketone derivative, and their uses as pesticides in agriculture, forms of pesticide compositions thereof, and methods for controlling pests using these compounds or compositions; wherein ring A, ring B, R 1, R 2, R 3, R 4, R 5, R 6, W, W 1, R a, R b, x and y are as described in the present invention.

  提供的是具有式（I）或立体异构体，N-氧化物和盐的4-氨基呋喃-2（5H）酮衍生物，以及4-氨基呋喃-2（5H）酮衍生物的制备方法，以及它们在农业中作为杀虫剂的用途，其杀虫剂组合物的形式，以及使用这些化合物或组合物控制害虫的方法;其中，环A，环B，R1，R2，R3，R4，R5，R6，W，W1，Ra，Rb，x和y如本发明所述。
• [EN] COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR TRAITER DES ÉTATS PATHOLOGIQUES ASSOCIÉS À UNE ACTIVITÉ DE STING
  申请人：IFM DUE INC

  公开号：WO2022150543A1

  公开（公告）日：2022-07-14

  This disclosure features compounds of Formula I (and their pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said compounds are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

  本公开涉及式I化合物（以及其药学上可接受的盐、水合物、共晶体和/或该化合物的药物组合物），其抑制（例如拮抗）干扰素基因刺激器（STING）。这些化合物是有用的，例如，用于治疗在其中增加（例如过度）STING激活（例如STING信号传导）有助于病理学和/或症状和/或疾病或障碍（例如癌症）在受试者（例如人类）中的进展的情况，疾病或障碍。本公开还涉及含有相同化合物的组合物以及使用和制备相同化合物的方法。
• ANTIVIRAL COMPOUNDS
  申请人：Gilead Pharmasset LLC

  公开号：EP3309157A1

  公开（公告）日：2018-04-18

  The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及抗病毒化合物、含有此类化合物的组合物、包括施用此类化合物的治疗方法，以及制备此类化合物的工艺和中间体。
• PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT
  申请人：Gilead Sciences, Inc.

  公开号：US20170190708A1

  公开（公告）日：2017-07-06

  The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
• COMPOSITIONS FOR THE TREATMENT OF PULMONARY FIBROSIS
  申请人：Vectus Biosystems Limited

  公开号：US20210130301A1

  公开（公告）日：2021-05-06

  The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.