1-(4-Fluorophenyl)-3-(2-oxo-1,3-dihydrobenzimidazol-5-yl)urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-Fluorophenyl)-3-(2-oxo-1,3-dihydrobenzimidazol-5-yl)urea
• 化学式: C₁₄H₁₁FN₄O₂
• 分子量: 286.26
• InChiKey: QHBZJKYNYFDRQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  82.3
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• [EN] SMALL MOLECULE GRB2 STABILIZERS FOR RAS MAP KINASE INHIBITION<br/>[FR] STABILISATEURS GRB2 À PETITES MOLÉCULES POUR INHIBITION DE LA MAP KINASE RAS
  申请人：UNIV TEXAS

  公开号：WO2020186202A1

  公开（公告）日：2020-09-17

  The present disclosure compounds of the formula (I-A) or (I), wherein the variables are defined herein, as well as pharmaceutical compositions thereof. The present disclosure also provides methods for the use of said compounds and/or pharmaceutical compositions, such as in the treatment of cancer. The present disclosure also provides methods for the use of compounds of the formula (III), wherein the variables are defined herein.

  本公开涉及公式（I-A）或（I）的化合物，其中变量在此定义，以及其制药组合物。本公开还提供了使用所述化合物和/或制药组合物的方法，例如用于治疗癌症。本公开还提供了使用公式（III）的化合物的方法，其中变量在此定义。
• SMALL MOLECULE GRB2 STABILIZERS FOR RAS MAP KINASE INHIBITION
  申请人：Board of Regents, The University of Texas System

  公开号：US20220151991A1

  公开（公告）日：2022-05-19

  The present disclosure compounds of the formula (I-A) or (I), wherein the variables are defined herein, as well as pharmaceutical compositions thereof. The present disclosure also provides methods for the use of said compounds and/or pharmaceutical compositions, such as in the treatment of cancer. The present disclosure also provides methods for the use of compounds of the formula (III), wherein the variables are defined herein.