N-[(1S)-1-[3-[4-chloro-3-(methanesulfonamido)-1-methylindazol-7-yl]-6-[3-methyl-3-[2-(methylamino)ethylamino]but-1-ynyl]pyridin-2-yl]-2-(3,5-difluorophenyl)ethyl]-2-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(1S)-1-[3-[4-chloro-3-(methanesulfonamido)-1-methylindazol-7-yl]-6-[3-methyl-3-[2-(methylamino)ethylamino]but-1-ynyl]pyridin-2-yl]-2-(3,5-difluorophenyl)ethyl]-2-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]acetamide
• 化学式: C₄₀H₃₉ClF₇N₉O₃S
• 分子量: 894.3
• InChiKey: JWCQMVRGQHSLJF-GKRYNVPLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  61
• 可旋转键数：
  15
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  156
• 氢给体数：
  4
• 氢受体数：
  16

文献信息

• [EN] THERAPEUTIC COMPOUNDS<br/>[FR] COMPOSÉS THÉRAPEUTIQUES
  申请人：GILEAD SCIENCES INC

  公开号：WO2014134566A2

  公开（公告）日：2014-09-04

  Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.