2-(3H-dithiol-3-yl)pyridine;1-hydroperoxyperoxytetratriacontane;1-hydroxypyrrolidine-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(3H-dithiol-3-yl)pyridine;1-hydroperoxyperoxytetratriacontane;1-hydroxypyrrolidine-2,5-dione
• 化学式: C46H82N2O7S2
• 分子量: 839.3
• InChiKey: KVLGZJYDZKSTAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.4
• 重原子数：
  57
• 可旋转键数：
  36
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  169
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• [EN] DERIVATIVES OF AMANITA TOXINS AND THEIR CONJUGATION TO A CELL BINDING MOLECULE<br/>[FR] DÉRIVÉS DE TOXINES D'AMANITES ET LEUR CONJUGAISON À UNE MOLÉCULE DE LIAISON CELLULAIRE
  申请人：HANGZHOU DAC BIOTECH CO LTD

  公开号：WO2017046658A1

  公开（公告）日：2017-03-23

  Derivatives of Amernita toxins of Formula (I), wherein, formula (a) R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8, R 9, R 10, X, L, m, n and Q are defined herein. The preparation of the derivatives. The therapeutic use of the derivatives in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.

  Amernita毒素的衍生物的化学式（I），其中，化学式（a）中的R 1、R 2、R 3、R 4、R 5、R 6、R 7、R 8、R 9、R 10、X、L、m、n和Q在此处被定义。这些衍生物的制备。这些衍生物在靶向治疗癌症、自身免疫性疾病和传染病中的治疗用途。
• [EN] NOVEL CYTOTOXIC AGENTS FOR CONJUGATION OF DRUGS TO CELL BINDING MOLECULE<br/>[FR] NOUVEAUX AGENTS CYTOTOXIQUES POUR LA CONJUGAISON DE MÉDICAMENTS AVEC LA MOLÉCULE DE LIAISON CELLULAIRE
  申请人：HANGZHOU DAC BIOTECH CO LTD

  公开号：WO2015028850A1

  公开（公告）日：2015-03-05

  Provided are cytotoxic agents, pyrrolo[2,1-c][1,4]benzodiazepine (PBD) derivatives, their conjugates with a cell-binding agent, the preparation and the therapeutic uses in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.

  提供了细胞毒性药物，吡咯并[2,1-c][1,4]苯二氮杂环己烷（PBD）衍生物，它们与细胞结合剂的结合物，以及在靶向治疗癌症、自身免疫性疾病和传染病中的制备和治疗用途。
• NOVEL CYTOTOXIC AGENTS FOR CONJUGATION TO A CELL BINDING MOLECULE
  申请人：HANGZHOU DAC BIOTECH CO., LTD

  公开号：US20160207949A1

  公开（公告）日：2016-07-21

  The present invention is related to novel cytotoxic agents, pyrrolo[2,1-c][1,4]benzodiazepine (PBD) derivatives, their conjugates with a cell-binding agent, the preparation and the therapeutic uses in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.

  本发明涉及一种新型细胞毒性剂，吡咯并[2,1-c][1,4]苯二氮平（PBD）衍生物，其与细胞结合剂的结合物，以及在靶向治疗癌症，自身免疫性疾病和传染病方面的制备和治疗用途。
• A NOVEL COMPLEX COMPRISING A CELL PENETRATING PEPTIDE, A CARGO AND A TLR PEPTIDE AGONIST FOR TREATMENT OF COLORECTAL CANCER
  申请人：Amal Therapeutics SA

  公开号：EP3693009A1

  公开（公告）日：2020-08-12

  The present invention provides a novel complex for use in the prevention and/or treatment of colorectal cancer, the complex comprising a) a cell penetrating peptide, b) at least one antigen or antigenic epitope, and c) at least one TLR peptide agonist, wherein the components a) - c) are covalently linked. In particular, compositions for use in the prevention and/or treatment of colorectal cancer, such as a pharmaceutical compositions and vaccines are provided.

  本发明提供了一种用于预防和/或治疗结直肠癌的新型复合物，该复合物包括 a) 细胞穿透肽，b) 至少一种抗原或抗原表位，以及 c) 至少一种 TLR 肽激动剂，其中 a) - c) 组份共价连接。特别是提供了用于预防和/或治疗结直肠癌的组合物，如药物组合物和疫苗。
• TARGETING M2-LIKE TUMOR-ASSOCIATED MACROPHAGES BY USING MELITTIN-BASED PRO-APOPTOTIC PEPTIDE
  申请人：Twinpigbiolab Inc.

  公开号：EP3789041A1

  公开（公告）日：2021-03-10

  The present invention relates to a melittin-anticancer drug conjugate in which melittin and an anticancer drug are conjugated, and to a method of preparing a melittin-anticancer drug conjugate by connecting melittin and an anticancer drug. A conjugate of the present invention is an anticancer material for targeting M2-type tumor-associated macrophages (TAM) and exhibits an excellent effect of selectively selecting M2-type tumor-associated macrophages (TAM), and thus may be used for a use of drug delivery for targeting M2-type tumor-associated macrophages.

  本发明涉及一种由美洛汀和抗癌药物共轭的美洛汀-抗癌药物共轭物，以及通过连接美洛汀和抗癌药物制备美洛汀-抗癌药物共轭物的方法。本发明的共轭物是一种靶向 M2 型肿瘤相关巨噬细胞（TAM）的抗癌材料，在选择性选择 M2 型肿瘤相关巨噬细胞（TAM）方面表现出优异的效果，因此可用于靶向 M2 型肿瘤相关巨噬细胞的给药用途。