tert-butyl N-(3-bromoanilino)-N-ethylcarbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-(3-bromoanilino)-N-ethylcarbamate
• 化学式: C₁₃H₁₉BrN₂O₂
• 分子量: 315.21
• InChiKey: HRTOLBQHSQPXLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• CaMKII INHIBITORS AND USES THEREOF
  申请人：Allosteros Therapeutics, Inc.

  公开号：EP2964225B1

  公开（公告）日：2018-08-08
• [EN] CaMKII INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE CAMKII ET LEURS UTILISATIONS
  申请人：ALLOSTEROS THERAPEUTICS INC

  公开号：WO2014138212A1

  公开（公告）日：2014-09-12

  The present invention provides compounds useful as inhibitors of Ca2+/calmodulindependent protein kinase (CaMKII), compositions thereof, and methods of using the same. Cardiovascular disease remains the number one cause of death in developed countries. Furthermore, incidence of cardiovascular disease has increased dramatically in developing countries. Although cardiovascular disease usually affects older adults, the antecedents of cardiovascular disease, notably atherosclerosis, begin in early life, making primary prevention efforts necessary from childhood.