[[(2E)-2-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethylidene]-3,4-dihydrochromen-4-yl]amino]-diphenyl-sulfidophosphanium | 1257099-23-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: [[(2E)-2-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethylidene]-3,4-dihydrochromen-4-yl]amino]-diphenyl-sulfidophosphanium
• CAS: 1257099-23-2
• 化学式: C₂₇H₂₈NO₃PS
• 分子量: 477.564
• InChiKey: PMRCMSVLBJBGMV-FMQUCBEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  48.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-(2-hydroxy-benzylidene)-P,P-diphenylphosphinothioic amide 、 tert-butyl buta-2,3-dienoate 在 三丁基膦 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以43%的产率得到[[(2E)-2-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethylidene]-3,4-dihydrochromen-4-yl]amino]-diphenyl-sulfidophosphanium
  参考文献：
  名称：

  Synthesis of Functionalized Chromans by PⁿBu₃-Catalyzed Reactions of Salicylaldimines and Salicylaldehydes with Allenic Ester

  摘要：

  P(n)Bu3-catalyzed cyclization reactions of salicylaldimines and salicylaldehydes with ethyl 2,3-butadienoate gave the corresponding functionalized chromans in moderate to good yields in THF under mild conditions. The new reaction provides a new method for the synthesis of biologically active chroman products.

  DOI：

  10.1021/ol102461c

文献信息

• Synthesis of Functionalized Chromans by P^<i>n</i>Bu₃-Catalyzed Reactions of Salicylaldimines and Salicylaldehydes with Allenic Ester
  作者：Yin-Wei Sun、Xiao-Yang Guan、Min Shi

  DOI：10.1021/ol102461c

  日期：2010.12.17

  P(n)Bu3-catalyzed cyclization reactions of salicylaldimines and salicylaldehydes with ethyl 2,3-butadienoate gave the corresponding functionalized chromans in moderate to good yields in THF under mild conditions. The new reaction provides a new method for the synthesis of biologically active chroman products.