2-[4-(2-Chlorophenyl)phenyl]-4-[[2-[4-(2-cyanophenyl)piperazin-1-yl]-2-oxoacetyl]amino]-2-hydroxypentanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-(2-Chlorophenyl)phenyl]-4-[[2-[4-(2-cyanophenyl)piperazin-1-yl]-2-oxoacetyl]amino]-2-hydroxypentanoic acid
• 英文别名: 2-[4-(2-chlorophenyl)phenyl]-4-[[2-[4-(2-cyanophenyl)piperazin-1-yl]-2-oxoacetyl]amino]-2-hydroxypentanoic acid
• 化学式: C₃₀H₂₉ClN₄O₅
• 分子量: 561.0
• InChiKey: ZSKYEVIUSDHLLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  40
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  134
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• NEPRILYSIN INHIBITORS
  申请人：Theravance Biopharma R&D IP, LLC

  公开号：EP2964616A1

  公开（公告）日：2016-01-13
• [EN] NEPRILYSIN INHIBITORS<br/>[FR] INHIBITEURS DE LA NÉPRILYSINE
  申请人：THERAVANCE BIOPHARMA R & D IP LLC

  公开号：WO2014138053A1

  公开（公告）日：2014-09-12

  In one aspect, the invention relates to compounds having the formula: (I) where R1-R5 and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.