2-[3-[2-(2-aminoanilino)-2-oxoethyl]phenyl]-N-(2-aminophenyl)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[3-[2-(2-aminoanilino)-2-oxoethyl]phenyl]-N-(2-aminophenyl)acetamide
• 化学式: C₂₂H₂₂N₄O₂
• 分子量: 374.4
• InChiKey: LQKHMRGYBPELKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  110
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• US20140256776A1
  申请人：——

  公开号：US20140256776A1

  公开（公告）日：2014-09-11
• TREATMENT OF CANCER AND OTHER CONDITIONS USING A TRANSCRIPTION FACTOR MODULATOR
  申请人：C & C BIOPHARMA, LLC

  公开号：US20150374646A1

  公开（公告）日：2015-12-31

  The present disclosure provides novel methods for treating cancer and conditions regulatable by a transcription factor and/or cofactor using specific compounds, as well as compositions, and pharmaceutical formulations. In certain embodiments, the compounds are transcription factor modulators.
• [EN] TREATMENT OF CANCER AND OTHER CONDITIONS USING A TRANSCRIPTION FACTOR MODULATOR<br/>[FR] TRAITEMENT DU CANCER ET D'AUTRES ÉTATS PATHOLOGIQUES À L'AIDE D'UN MODULATEUR DE FACTEUR DE TRANSCRIPTION
  申请人：C & C BIOPHARMA LLC

  公开号：WO2014138505A1

  公开（公告）日：2014-09-12

  The present disclosure provides novel methods for treating cancer and conditions regulatable by a transcription factor and/or cofactor using specific compounds, as well as compositions, and pharmaceutical formulations. In certain embodiments, the compounds are transcription factor modulators. Hematological cancer includes leukemia, lymphoma, and myeloma. Leukemia is a type of cancer of blood or bone marrow characterized by an abnormal increase of immature leukocytes. The exact cause of leukemia is unknown; however, it generally results from DNA mutations in stem cells.