2,2-Ditert-butyl-1-(4-methylphenyl)-3-phenylazasiliridine | 951797-75-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-Ditert-butyl-1-(4-methylphenyl)-3-phenylazasiliridine
• CAS: 951797-75-4
• 化学式: C₂₂H₃₁NSi
• 分子量: 337.58
• InChiKey: IBSWOSHIPXBFAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.64
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  甲醇 、 2,2-Ditert-butyl-1-(4-methylphenyl)-3-phenylazasiliridine 以 甲苯 为溶剂， 反应 1.0h， 以40%的产率得到N-[[ditert-butyl(methoxy)silyl]-phenylmethyl]-4-methylaniline
  参考文献：
  名称：

  Metal-Catalyzed Silylene Transfer to Imines:  Synthesis and Reactivity of Silaaziridines

  摘要：

  Metal-catalyzed silylene transfer to imines provides an efficient synthesis of silaaziridines. These strained cyclic silanes undergo selective bond-forming reactions, permitting the synthesis of nitrogen-containing compounds after protodesilylation of the resulting vinyl silane.

  DOI：

  10.1021/ol701424a
• 作为产物：
  描述：

  7,7-di-tert-butyl-7-silabicyclo[4.1.0]heptane 、 N亚苄基对甲苯胺 在 silver trifluoromethanesulfonate 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以73%的产率得到2,2-Ditert-butyl-1-(4-methylphenyl)-3-phenylazasiliridine
  参考文献：
  名称：

  Metal-Catalyzed Silylene Transfer to Imines:  Synthesis and Reactivity of Silaaziridines

  摘要：

  Metal-catalyzed silylene transfer to imines provides an efficient synthesis of silaaziridines. These strained cyclic silanes undergo selective bond-forming reactions, permitting the synthesis of nitrogen-containing compounds after protodesilylation of the resulting vinyl silane.

  DOI：

  10.1021/ol701424a

文献信息

• Dearomatization Reactions of Aryl-Substituted Silaaziridines
  作者：Zulimar Nevárez、K. A. Woerpel

  DOI：10.1021/jo801502x

  日期：2008.10.17

  Silaaziridines with an aryl group on either the carbon or the nitrogen atom undergo dearomatization reactions upon treatment with benzaldehyde. The reactions form new bonds ortho to the nitrogen substituents with high diastereoselectivity. These dearomatization processes likely are driven by relief of the considerable ring strain of the silaaziridine.
• Metal-Catalyzed Silylene Transfer to Imines:  Synthesis and Reactivity of Silaaziridines
  作者：Zulimar Nevárez、K. A. Woerpel

  DOI：10.1021/ol701424a

  日期：2007.9.1

  Metal-catalyzed silylene transfer to imines provides an efficient synthesis of silaaziridines. These strained cyclic silanes undergo selective bond-forming reactions, permitting the synthesis of nitrogen-containing compounds after protodesilylation of the resulting vinyl silane.