2-[(2,4-Difluorophenyl)methyl]-5-methyl-1,3,4-oxadiazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(2,4-Difluorophenyl)methyl]-5-methyl-1,3,4-oxadiazole
• 英文别名: 2-[(2,4-difluorophenyl)methyl]-5-methyl-1,3,4-oxadiazole
• 化学式: C₁₀H₈F₂N₂O
• 分子量: 210.18
• InChiKey: KMBFAUVOLFCZIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  38.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE-INHIBITING ACTIVITY
  申请人：Shionogi & Co., Ltd.

  公开号：EP3196201B1

  公开（公告）日：2021-04-28
• US20140256937A1
  申请人：——

  公开号：US20140256937A1

  公开（公告）日：2014-09-11
• POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE INHIBITORY ACTIVITY
  申请人：Shionogi & Co., Ltd.

  公开号：US20170226128A1

  公开（公告）日：2017-08-10

  The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.
• US9200009B2
  申请人：——

  公开号：US9200009B2

  公开（公告）日：2015-12-01