2-Methoxy-5-[[2-[2-(trifluoromethyl)pyrazol-3-yl]pyridin-3-yl]methoxy]pyridine-4-carbaldehyde

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Methoxy-5-[[2-[2-(trifluoromethyl)pyrazol-3-yl]pyridin-3-yl]methoxy]pyridine-4-carbaldehyde
• 英文别名: 2-methoxy-5-[[2-[2-(trifluoromethyl)pyrazol-3-yl]pyridin-3-yl]methoxy]pyridine-4-carbaldehyde
• 化学式: C₁₇H₁₃F₃N₄O₃
• 分子量: 378.3
• InChiKey: BUNGRUPDCZKKPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  79.1
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• US20140275152A1
  申请人：——

  公开号：US20140275152A1

  公开（公告）日：2014-09-18
• SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION
  申请人：Global Blood Therapeutics, Inc.

  公开号：US20170107199A1

  公开（公告）日：2017-04-20

  Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
• US9422279B2
  申请人：——

  公开号：US9422279B2

  公开（公告）日：2016-08-23