Detection reagents and electrode arrangements for multi-analyte diagnostic test elements, as well as methods of using the same
申请人:Roche Diabetes Care, Inc.
公开号:US11230727B2
公开(公告)日:2022-01-25
Detection reagents, multi-analyte test elements, test systems, and multi-analyte measuring methods are provided. In particular, multi-analyte test elements have (1) a first working electrode and first counter electrode pair covered with a first analyte-specific reagent that includes an enzyme, a coenzyme and a first mediator and have (2) a second working electrode covered with a second analyte-specific reagent that includes an enzyme, a coenzyme and a second mediator, where the second mediator is different than the first mediator. The single counter electrode can be used as the counter electrode for both the first and second analyte measurements at their respective working electrodes. Moreover, the mediator concentrations, measurement ranges, and applied potential differences are not the same for each analyte-specific measurement.
提供了检测试剂、多分析物测试元件、测试系统和多分析物测量方法。特别是,多分析物测试元件具有(1)覆盖有第一分析物特异性试剂(包括酶、辅酶和第一介质)的第一工作电极和第一对反电极,以及(2)覆盖有第二分析物特异性试剂(包括酶、辅酶和第二介质)的第二工作电极,其中第二介质不同于第一介质。单个对电极可用作在各自工作电极上测量第一和第二分析物的对电极。此外,每种特定分析物测量的介质浓度、测量范围和应用电位差都不相同。