[5-chloro-4-methyl-2-(triazol-2-yl)phenyl]-[2-[3-[2-(trifluoromethoxy)phenyl]-1H-1,2,4-triazol-5-yl]azetidin-1-yl]methanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [5-chloro-4-methyl-2-(triazol-2-yl)phenyl]-[2-[3-[2-(trifluoromethoxy)phenyl]-1H-1,2,4-triazol-5-yl]azetidin-1-yl]methanone
• 化学式: C₂₂H₁₇ClF₃N₇O₂
• 分子量: 503.9
• InChiKey: QTOBFNXXJGXRBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] AZETIDINE AMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS<br/>[FR] DÉRIVÉS D'AMIDE D'AZÉTIDINE EN TANT QU'ANTAGONISTES DES RÉCEPTEURS D'ORÉXINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2014141065A1

  公开（公告）日：2014-09-18

  The present invention relates to azetidine amide derivatives derivatives of formula (I) wherein rings A1 A2 and A3 are as described in the description, to pharmaceutically acceptable salts thereof, to their preparation, to pharmaceutical compositions containing one or more compounds of formula (I), and to their use as pharmaceuticals, especially to their use as orexin receptor antagonists.

  本发明涉及式(I)的吡嗪酰胺衍生物衍生物，其中环A1、A2和A3如描述中所述，其药学上可接受的盐，其制备方法，含有一种或多种式(I)化合物的药物组合物，以及它们作为药物的用途，特别是它们作为促进睡眠的药物。
• AZETIDINE AMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：US20160024064A1

  公开（公告）日：2016-01-28

  The present invention relates to azetidine amide derivatives derivatives of formula (I) wherein rings A 1 A 2 and A 3 are as described in the description, to pharmaceutically acceptable salts thereof, to their preparation, to pharmaceutical compositions containing one or more compounds of formula (I), and to their use as pharmaceuticals, especially to their use as orexin receptor antagonists.

  本发明涉及一种式（I）的氮杂环酰胺衍生物，其中环A1、A2和A3如说明书所述，其药学上可接受的盐，其制备方法，包含一种或多种式（I）化合物的制药组合物，以及它们作为药物的用途，特别是作为促进睡眠的药物，尤其是作为促进睡眠的药物。
• US9403813B2
  申请人：——

  公开号：US9403813B2

  公开（公告）日：2016-08-02