N-[[(2R,3S)-8-[2-(4-fluorophenyl)ethynyl]-5-(1-hydroxypropan-2-yl)-3-methyl-6-oxo-3,4-dihydro-2H-pyrido[2,3-b][1,5]oxazocin-2-yl]methyl]-2-methoxy-N-methylacetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[[(2R,3S)-8-[2-(4-fluorophenyl)ethynyl]-5-(1-hydroxypropan-2-yl)-3-methyl-6-oxo-3,4-dihydro-2H-pyrido[2,3-b][1,5]oxazocin-2-yl]methyl]-2-methoxy-N-methylacetamide
• 化学式: C₂₆H₃₀FN₃O₅
• 分子量: 483.5
• InChiKey: DOLREMKIPLJTKG-IYWNWZSTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  92.2
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF
  申请人：The Broad Institute, Inc.

  公开号：EP2970900A1

  公开（公告）日：2016-01-20
• [EN] COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS D'INDUCTION DE LA PROLIFÉRATION ET DE LA DIFFÉRENCIATION DE CELLULES ET PROCÉDÉS D'UTILISATION CORRESPONDANTS
  申请人：BROAD INST INC

  公开号：WO2014144125A1

  公开（公告）日：2014-09-18

  The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention. Liver disease affects more than 500 million people worldwide. Organ transplantation is the gold standard for treatment of liver failure, but organ shortages are acute.