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[3-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methyl]pyridin-2-yl] hydrogen carbonate

中文名称
——
中文别名
——
英文名称
[3-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methyl]pyridin-2-yl] hydrogen carbonate
英文别名
[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]pyridin-2-yl] hydrogen carbonate
[3-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methyl]pyridin-2-yl] hydrogen carbonate化学式
CAS
——
化学式
C14H9F2NO5
mdl
——
分子量
309.22
InChiKey
YNEPIUIGCFNVRY-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3.5
  • 重原子数:
    22
  • 可旋转键数:
    4
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.14
  • 拓扑面积:
    77.9
  • 氢给体数:
    1
  • 氢受体数:
    8

文献信息

  • CARBAMATE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS
    申请人:The Regents of the University of California
    公开号:US20160068482A1
    公开(公告)日:2016-03-10
    Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein and methods for formulating these compounds as pharmaceutical compositions which include these compounds. Also described herein are methods of inhibiting NAAA in order to sustain the levels of palmitoylethanolamide (PEA) and other N-acylethanolamines (NAE) that are substrates for NAAA, in conditions characterized by reduced concentrations of NAE. Also, described here are methods of treating and ameliorating pain, inflammation, inflammatory diseases, and other disorders in which modulation of fatty acid ethanolamides is clinically or therapeutically relevant or in which decreased levels of NAE are associated with the disorder.
    本文描述了一些化合物和药物组成物,它们可以抑制N-酰基乙醇胺酸酰化酶(NAAA)。本文还描述了合成这些化合物的方法,以及将它们制成药物组成物的方法。同时,本文还描述了抑制NAAA以维持棕榈酰乙醇胺(PEA)和其他N-酰基乙醇胺(NAE)的水平的方法,这些物质是NAAA的底物,并且在NAE浓度降低的情况下有用。此外,本文还描述了治疗和缓解疼痛、炎症、炎症性疾病和其他疾病的方法,这些疾病中脂肪酸乙醇胺的调节在临床或治疗上是相关的,或者NAE的浓度降低与该疾病有关。
  • US9828338B2
    申请人:——
    公开号:US9828338B2
    公开(公告)日:2017-11-28
  • [EN] CARBAMATE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS<br/>[FR] DÉRIVÉS DE CARBAMATE D'INHIBITEURS D'AMIDASE ACIDE DE N-ACYLÉTHANOLAMINE (NAAA) À BASE DE LACTAME
    申请人:UNIV CALIFORNIA
    公开号:WO2014144836A2
    公开(公告)日:2014-09-18
    Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein and methods for formulating these compounds as pharmaceutical compositions which include these compounds. Also described herein are methods of inhibiting NAAA in order to sustain the levels of palmitoylethanolamide (PEA) and other N-acylethanolamines (NAE) that are substrates for NAAA, in conditions characterized by reduced concentrations of NAE. Also, described here are methods of treating and ameliorating pain, inflammation, inflammatory diseases, and other disorders in which modulation of fatty acid ethanolamides is clinically or therapeutically relevant or in which decreased levels of NAE are associated with the disorder.
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