2-[7-[(3-Bromophenyl)methyl]-1-(2-methoxyethyl)-3-methyl-2,6-dioxopurin-8-yl]sulfanylbutanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-[7-[(3-Bromophenyl)methyl]-1-(2-methoxyethyl)-3-methyl-2,6-dioxopurin-8-yl]sulfanylbutanoic acid
• 英文别名: 2-[7-[(3-bromophenyl)methyl]-1-(2-methoxyethyl)-3-methyl-2,6-dioxopurin-8-yl]sulfanylbutanoic acid
• 化学式: C₂₀H₂₃BrN₄O₅S
• 分子量: 511.4
• InChiKey: HTSPXFUVLVZMBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  130
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
  申请人：The Johns Hopkins University

  公开号：EP2968237A1

  公开（公告）日：2016-01-20
• [EN] METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR AMÉLIORER LA FONCTION COGNITIVE
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2014144663A1

  公开（公告）日：2014-09-18

  This invention relates to methods and compositions for treating cognitive impairment associated with central nervous system (CNS) disorders. In particular, it relates to the use of inhibitors of synaptic vesicle glycoprotein 2A (SV2A), alone or in combination with valproate, in treating cognitive impairment associated with central nervous system (CNS) disorders in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment.