3-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)azetidine-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• 英文名称: 3-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)azetidine-1-carboxylic acid
• 英文别名: 3-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)azetidine-1-carboxylic acid
• 化学式: C₇H₇F₆NO₃
• 分子量: 267.13
• InChiKey: JFVCUZXFFZHPCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• sGC stimulators
  申请人：Cyclerion Therapeutics, Inc.

  公开号：US10639308B2

  公开（公告）日：2020-05-05

  Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

  本文描述了式 I′ 和 I 的化合物，它们可用作 sGC 的刺激剂，特别是 NO 依赖性、血红素依赖性刺激剂。这些化合物还可用于治疗、预防或控制本文公开的各种疾病。
• SGC STIMULATORS
  申请人：Ironwood Pharmaceuticals, Inc.

  公开号：EP2970243A2

  公开（公告）日：2016-01-20
• sGC STIMULATORS
  申请人：Ironwood Pharmaceuticals, Inc.

  公开号：US20170137439A1

  公开（公告）日：2017-05-18

  Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
• [EN] SGC STIMULATORS<br/>[FR] STIMULATEURS DE SGC
  申请人：NAKAI TAKASHI

  公开号：WO2014144100A2

  公开（公告）日：2014-09-18

  Compounds of Formulae (I') and (I) are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.