4-benzyl-5-(oxomethylidene)-1,3-oxazolidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 4-benzyl-5-(oxomethylidene)-1,3-oxazolidin-2-one
• 化学式: C₁₁H₉NO₃
• 分子量: 203.19
• InChiKey: GQSPPTQUXGXARL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS
  申请人：Cayman Chemical Company, Incorporated

  公开号：EP2989098A2

  公开（公告）日：2016-03-02
• METHODS, SYSTEMS, AND COMPOSITIONS FOR PROMOTING BONE GROWTH
  申请人：Cayman Chemical Company, Incorporated

  公开号：EP3021879A2

  公开（公告）日：2016-05-25
• [EN] LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS<br/>[FR] COMPOSÉS DE LACTAME EN TANT QU'ANTAGONISTES SÉLECTIFS DU RÉCEPTEUR EP4 POUR UNE UTILISATION DANS LE TRAITEMENT DE MALADIES ET D'ÉTATS MÉDIÉS PAR L'EP4
  申请人：CAYMAN CHEMICAL CO INC

  公开号：WO2014144584A2

  公开（公告）日：2014-09-18

  Disclosed herein are compounds of formula (I) wherein L1, L2, L3, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.
• [EN] METHODS, SYSTEMS, AND COMPOSITIONS FOR PROMOTING BONE GROWTH<br/>[FR] PROCÉDÉS, SYSTÈMES ET COMPOSITIONS POUR ACTIVER LA CROISSANCE OSSEUSE
  申请人：CAYMAN CHEMICAL CO INC

  公开号：WO2015009991A2

  公开（公告）日：2015-01-22

  The present invention relates to novel bone compositions for locally delivering a therapeutic agent to the site of a bone defect. Therapeutic agents may promote repair of the bone defect and/or treat conditions or disorders such as pain, inflammation, cancer, and infection. The compositions include calcium phosphate cements and a demineralized bone matrix or a collagen sponge. The compositions are useful for implantation in a patient at the site of a bone defect.