[5-Amino-4-(2-methoxyethoxy)-3-(oxan-4-yl)pyrazol-1-yl]-phenylmethanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [5-Amino-4-(2-methoxyethoxy)-3-(oxan-4-yl)pyrazol-1-yl]-phenylmethanone
• 英文别名: [5-amino-4-(2-methoxyethoxy)-3-(oxan-4-yl)pyrazol-1-yl]-phenylmethanone
• 化学式: C₁₈H₂₃N₃O₄
• 分子量: 345.4
• InChiKey: ACKRWVKQYBALFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  88.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN
  申请人：VERSEON CORPORATION

  公开号：US20160046585A1

  公开（公告）日：2016-02-18

  There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin.
• SUBSTITUTED PYRAZOLE COMPOUNDS AS SERINE PROTEASE INHIBITORS
  申请人：VERSEON CORPORATION

  公开号：US20200109132A1

  公开（公告）日：2020-04-09

  There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin and/or kallikrein, which compounds include substituted pyrazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which diseases or disorders are amenable to treatment or prevention by the inhibition of thrombin and/or kallikrein.
• US9951025B2
  申请人：——

  公开号：US9951025B2

  公开（公告）日：2018-04-24
• [EN] HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN<br/>[FR] HALOGÉNOPYRAZOLES EN TANT QU'INHIBITEURS DE THROMBINE
  申请人：VERSEON INC

  公开号：WO2014146059A1

  公开（公告）日：2014-09-18

  There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin.