N-[4-(1,1,1,3,3-pentafluoro-2-hydroxybutan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-(1,1,1,3,3-pentafluoro-2-hydroxybutan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
• 化学式: C₁₈H₁₅F₈NO₃S
• 分子量: 477.4
• InChiKey: CLCGZZPVHFRKMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• METHOD AND COMPOSITIONS FOR DETECTING BINDING TO THE PREGNANE X RECEPTOR
  申请人：ST. JUDE CHILDREN'S RESEARCH HOSPITAL

  公开号：US20160033531A1

  公开（公告）日：2016-02-04

  In one aspect, the invention relates to compounds useful as fluorescence assay probes, methods of making same, and methods of using same to assay ligand binding interactions with PXR. In various aspects, the invention pertains to compositions comprising a polypeptide comprising a pregnane X receptor polypeptide, or a ligand binding fragment polypeptide thereof; and a molecule comprising a BODIPY residue and a vinca alkaloid residue. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  该发明涉及用作荧光分析探针的化合物，制备方法以及使用它们来检测与PXR的配体结合相互作用的方法。在不同的方面，该发明涉及包含一个孕烷X受体多肽或其配体结合片段多肽的多肽组合物；和一个包含BODIPY残基和长春碱残基的分子的组合物。本摘要旨在作为特定领域搜索的扫描工具，并不意味着对本发明的限制。
• [EN] METHODS AND COMPOSITIONS FOR DETECTING BINDING TO THE PREGNANE X RECEPTOR<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR DÉTECTER LA LIAISON AU RÉCEPTEUR X DE PRÉGNANE
  申请人：ST JUDE CHILDRENS RES HOSPITAL

  公开号：WO2014145202A1

  公开（公告）日：2014-09-18

  In one aspect, the invention relates to compounds useful as fluorescence assay probes, methods of making same, and methods of using same to assay ligand binding interactions with PXR. In various aspects, the invention pertains to compositions comprising a polypeptide comprising a pregnane X receptor polypeptide, or a ligand binding fragment polypeptide thereof; and a molecule comprising a BODIPY residue and a vinca alkaloid residue. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.