5-碘苯并噻唑 | 89641-05-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 中文名称: 5-碘苯并噻唑
• 英文名称: 5-iodobenzo[d]thiazole
• 英文别名: 5-iodo-1,3-benzothiazole
• CAS: 89641-05-4
• 化学式: C₇H₄INS
• 分子量: 261.086
• InChiKey: GLKZKYSZPVHLDK-UHFFFAOYSA-N

物化性质

• 沸点：
  316.8±15.0 °C(Predicted)
• 密度：
  2.034±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-碘苯并噻唑 在 三甲基氯硅烷 、 sodium hexamethyldisilazane 、 锌 作用下， 以 四氢呋喃 为溶剂， 反应 37.33h， 生成 ethyl 5-((diethoxyphosphoryl)difluoromethyl)benzo[d]thiazole-2-carboxylate
  参考文献：
  名称：

  [EN] 6-OXODECAHYDROPYRROLO[1,2-A][1,5]DIAZOCINE AND 6-OXODECAHYDRO-4H-PYRROLO[2,1-D][1,5]THIAZOCINE DERIVATIVES AS STAT3 AND STAT6 MODULATORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY CONDITIONS
  [FR] DÉRIVÉS DE 6-OXODÉCAHYDROPYRROLO [1,2-A] [1,5] DIAZOCINE ET DE 6-OXODÉCAHYDRO-4 H-PYRROLO [2,1-D] [1,5] THIAZOCINE EN TANT QUE MODULATEURS STAT3 ET STAT6 POUR LE TRAITEMENT DU CANCER ET D'ÉTATS INFLAMMATOIRES

  摘要：

  Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with STAT3 and/or STAT6, such as e.g. cancer and inflammatory conditions. Preferred compounds are 6-oxodecahydropyrrolo[1,2-a][1,5]diazocine and 6-oxodecahydro-4H-pyrrolo[2,1-d][1,5]thiazocine derivatives.

  公开号：

  WO2023164680A1
• 作为产物：
  描述：

  1,3-苯并噻唑-5-胺 在 盐酸 、 sodium nitrite 、 potassium iodide 作用下， 以 水 、 乙腈 为溶剂， 以52 %的产率得到5-碘苯并噻唑
  参考文献：
  名称：

  [EN] 6-OXODECAHYDROPYRROLO[1,2-A][1,5]DIAZOCINE AND 6-OXODECAHYDRO-4H-PYRROLO[2,1-D][1,5]THIAZOCINE DERIVATIVES AS STAT3 AND STAT6 MODULATORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY CONDITIONS
  [FR] DÉRIVÉS DE 6-OXODÉCAHYDROPYRROLO [1,2-A] [1,5] DIAZOCINE ET DE 6-OXODÉCAHYDRO-4 H-PYRROLO [2,1-D] [1,5] THIAZOCINE EN TANT QUE MODULATEURS STAT3 ET STAT6 POUR LE TRAITEMENT DU CANCER ET D'ÉTATS INFLAMMATOIRES

  摘要：

  Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with STAT3 and/or STAT6, such as e.g. cancer and inflammatory conditions. Preferred compounds are 6-oxodecahydropyrrolo[1,2-a][1,5]diazocine and 6-oxodecahydro-4H-pyrrolo[2,1-d][1,5]thiazocine derivatives.

  公开号：

  WO2023164680A1

文献信息

• Inhibitors of CYP 17
  申请人：BOCK Mark G.

  公开号：US20100331326A1

  公开（公告）日：2010-12-30

  The present invention provides compounds of Formula (I) and (II), or a pharmaceutically acceptable salts thereof, where R 53 , R 54 , p, q, and n are as defined herein. The compounds of the present invention have been found to be useful as 17α-hydroxylase/C 17,20 -lyase inhibitors.

  本发明提供了式(I)和(II)的化合物，或其药用可接受的盐， 其中R 53 ，R 54 ，p，q和n如本文所述定义。本发明的化合物被发现作为17α-羟化酶/C 17,20 -裂解酶抑制剂是有用的。
• INHIBITORS OF CYP 17
  申请人：BOCK Mark Gary

  公开号：US20140228394A1

  公开（公告）日：2014-08-14

  The present invention provides compounds of Formula (I) and (II), or a pharmaceutically acceptable salts thereof, where R 53 , R 54 , p, q, and n are as defined herein. The compounds of the present invention have been found to be useful as 17α-hydroxylase/C 17,20 -lyase inhibitors.

  本发明提供了公式(I)和(II)化合物，或其药学上可接受的盐，其中R53、R54、p、q和n的定义如本文所述。本发明的化合物已被发现可以作为17α-羟化酶/C17,20-裂解酶抑制剂使用。
• Electrically photosensitive particles for electrophoretic migration imaging processes
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0000596A1

  公开（公告）日：1979-02-07

  Electrically photosensitive particles for electrophoretic migration imaging processes. Electrically photosensitive particles (4) for use in electrophoretic migration imaging processes comprise a compound having the structure: or wherein m and n are zero, one or two; R1 and Rl each represents hydrogen, alkyl or aryl; Y represents 0 or S; L'through L' represent hydrogen, alkyl or aryl, or in addition, either L' and L2 or any two of L3, L4 and L' together represent the atoms needed to complete a carbocyclic ring; A' represents a basic heterocyclic nucleus and A2 represents the A1 nuclei, an aryl group or a heterocyclic nucleus. The particles (4) can be used in an electrophoretic migration imaging process which consists in placing them between two electrodes (1) and (5) and submitting them to an activating radiation and an electric field for obtaining an image on electrodes (1) and (5).

  用于电泳迁移成像过程的电致发光颗粒。 用于电泳迁移成像过程的电致发光颗粒（4）由具有以下结构的化合物组成： 或 其中 m 和 n 为 0、1 或 2；R1 和 Rl 各自代表氢、烷基或芳基；Y 代表 0 或 S；L'至 L' 代表氢、烷基或芳基，或此外，L'和 L2 或 L3、L4 和 L' 中的任意两个加在一起代表完成碳环所需的原子；A' 代表基本杂环核，A2 代表 A1 核、芳基或杂环核。 微粒（4）可用于电泳迁移成像过程，该过程包括将微粒（4）置于两个电极（1）和（5）之间，并将其置于活化辐射和电场中，以获得电极（1）和（5）上的图像。
• Electrically photosensitive particles for photoelectrophoretic migration imaging processes
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0000599A1

  公开（公告）日：1979-02-07

  Electrically photosensitive particles for electrophoretic migration imaging processes. Electrophotosensitive particles (4) for electrophoretic migration imaging processes comprise a compound having the structure or wherein m and n are zero, one or two; L'to L' are hydrogen, alkyl, cyano aralkyl, aryl or heterocyclyl, and in addition, any two of L1, L2 and L3 and any two of L4, L5,L6 and L' may together represent the atoms needed to complete a carbocyclic ring having from 5-10 carbon atoms; A' represents an alkyl, aryl group or a heterocyclic nucleus; A2 represents a basic heterocyclic nucleus; B1 and B2 represent cyano, carboxy, alkoxycarbonyl, aryloxycarbonyl, alkylsulfonyl, acyl, arylcarbonyl, heteroyl, nitro, nitro substituted aryl, sulfonyl, fluorosulfonyl, trifluoromethylsulfonyl, carbamoyl, arylcarbamoyl or alkylcarbamoyl. The particles (4) can be used in an.electrophoretic migration imaging process which consists in placing them between two electrodes (1) and (5) and submitting them to an activating radiation and an electric field for obtaining an f image on electrodes (1) and (5).

  用于电泳迁移成像过程的电光敏颗粒。 用于电泳迁移成像过程的电致发光颗粒（4）由具有以下结构的化合物组成 或 其中m和n为0、1或2；L'至L'为氢、烷基、氰基芳基、芳基或杂环基，此外，L1、L2和L3中的任意两个以及L4、L5、L6和L'中的任意两个可共同代表完成具有5-10个碳原子的碳环所需的原子；A'代表烷基、芳基或杂环核；A2 代表基本杂环核；B1 和 B2 代表氰基、羧基、烷氧羰基、芳氧羰基、烷基磺酰基、酰基、芳基羰基、杂酰基、硝基、硝基取代的芳基、磺酰基、氟磺酰基、三氟甲基磺酰基、氨基甲酰基、芳基氨基甲酰基或烷基氨基甲酰基。 微粒（4）可用于电泳迁移成像过程，该过程包括将微粒（4）置于两个电极（1）和（5）之间，并将其置于活化辐射和电场中，以在电极（1）和（5）上获得 f 图像。
• Electrophoretic migration imaging process and dispersion
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0005652A2

  公开（公告）日：1979-11-28

  Electrophoretic migration imaging process and dispersion employing electrically photosensitive compounds having the structure or wherein R represents a basic heterocyclic nucleus, hydrogen, alkyl, aryl, aralkyl, ureido, thioureido, hydroxy, anilino, or amidino; A1 represents a basic heterocyclic nucleus; A2 represents aryl or may be the same as A1; G represents oxygen or sulphur; m is 0, 1, 2 or 3; n is 0 or 1; and L', L2, L3, L4 and L5 represent hydrogen, alkyl or aryl.

  采用具有以下结构的电致发光化合物的电泳迁移成像工艺和分散体 或 其中 R 代表基本杂环核、氢、烷基、芳基、芳烷基、脲基、硫脲基、羟基、苯胺基或脒基； A1 代表基本杂环核； A2 代表芳基或可与 A1 相同； G 代表氧或硫； m 是 0、1、2 或 3； n 是 0 或 1；以及 L'、L2、L3、L4 和 L5 代表氢、烷基或芳基。