2-[[6-[[Bis(2-oxoethyl)amino]methyl]-4-dodecoxypyridin-2-yl]methyl-(2-oxoethyl)amino]acetaldehyde

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-[[6-[[Bis(2-oxoethyl)amino]methyl]-4-dodecoxypyridin-2-yl]methyl-(2-oxoethyl)amino]acetaldehyde
• 英文别名: 2-[[6-[[bis(2-oxoethyl)amino]methyl]-4-dodecoxypyridin-2-yl]methyl-(2-oxoethyl)amino]acetaldehyde
• 化学式: C₂₇H₄₃N₃O₅
• 分子量: 489.6
• InChiKey: NCZPGTUTZPCEPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  35
• 可旋转键数：
  24
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  96.9
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Particles comprising luminescent lanthanide complexes
  申请人：Centre National de la Recherche Scientifique (CNRS)

  公开号：EP2777715A1

  公开（公告）日：2014-09-17

  The present invention relates to particles, useful for drug release detection, comprising: - at least one luminescent metal complex of formula [Ln].[L], wherein: - Ln is a lanthanide ion, - L is an organic ligand comprising a hydrophilic unit with at least 6 chelating groups chosen from the group consisting of hydroxyl, carboxyl, optionally in the carboxylate form, carbonyl, ether, phosphonate, phosphinate, thiolate, amino and imino functions, and - at least one drug comprising a conjugated aromatic system, wherein said drug is not covalently bonded to the metal complex, said particle having a size comprised from 3 nm to 2 000 nm, and wherein the distribution of the metal complex and the drug within the particle is such that the mean distance between a drug molecule and a metal complex is less than 15 nm.

  本发明涉及用于药物释放检测的微粒，包括 - 至少一种式[Ln].[L]的发光金属复合物，其中： - Ln 是镧系离子、 - L 是由至少 6 个螯合基团组成的亲水单元的有机配体，这些螯合基团选自由羟基、羧基（可选羧酸盐形式）、羰基、醚、膦酸盐、膦酸盐、硫酸酯、氨基和亚氨基功能组成的组，以及 - 至少一种由共轭芳香系统组成的药物，其中所述药物未与金属络合物共价键合、 所述颗粒的尺寸为 3 纳米至 2 000 纳米，其中金属络合物和药物在颗粒内的分布使得药物分子与金属络合物之间的平均距离小于 15 纳米。
• PARTICLES COMPRISING LUMINESCENT LANTHANIDE COMPLEXES
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

  公开号：US20160030599A1

  公开（公告）日：2016-02-04

  The present invention relates to particles, useful for drug release detection, comprising: at least one luminescent metal complex of formula [Ln].[L], wherein: Ln is a lanthanide ion, L is an organic ligand comprising a hydrophilic unit with at least 6 chelating groups chosen from the group consisting of hydroxyl, carboxyl, optionally in the carboxylate form, carbonyl, ether, phosphonate, phosphinate, thiolate, amino and imino functions, and at least one drug comprising a conjugated aromatic system, wherein said drug is not covalently bonded to the metal complex, said particle having a size comprised from 3 nm to 2000 nm, and wherein the distribution of the metal complex and the drug within the particle is such that the mean distance between a drug molecule and a metal complex is less than 15 nm.
• [EN] PARTICLES COMPRISING LUMINESCENT LANTHANIDE COMPLEXES<br/>[FR] PARTICULES COMPRENANT DES COMPLEXES LUMINESCENTS DE LANTHANIDES
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2014140203A1

  公开（公告）日：2014-09-18

  The present invention relates to particles, useful for drug release detection, comprising: at least one luminescent metal complex of formula [Ln].[L], wherein: Ln is a lanthanide ion, L is an organic ligand comprising a hydrophilic unit with at least 6 chelating groups chosen from the group consisting of hydroxyl, carboxyl, optionally in the carboxylate form, carbonyl, ether, phosphonate, phosphinate, thiolate, amino and imino functions, and - at least one drug comprising a conjugated aromatic system, wherein said drug is not covalently bonded to the metal complex, said particle having a size comprised from 3 nm to 2 000 nm, and wherein the distribution of the metal complex and the drug within the particle is such that the mean distance between a drug molecule and a metal complex is less than 15 nm.