3-[(3R)-6-(dimethylamino)hexan-3-yl]phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[(3R)-6-(dimethylamino)hexan-3-yl]phenol
• 化学式: C₁₄H₂₃NO
• 分子量: 221.34
• InChiKey: FAVXEBDEFPKGRI-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] PROCESS FOR THE PREPARATION OF TAPENTADOL VIA NOVEL INTERMEDIATE<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION DE TAPENTADOL PAR LE BIAIS D'UN NOUVEL INTERMÉDIAIRE
  申请人：IND SWIFT LAB LTD

  公开号：WO2014141296A2

  公开（公告）日：2014-09-18

  The present invention relates to a commercially viable and improved process for preparation of tapentadol of formula I and its pharmaceutically acceptable salts, Formula I via novel intermediates tertiary hydroxy protected sulfonyl compound of formula III. Formula III wherein R1 is selected from hydrogen, straight chain or branched alky I, aryl, aralkyl, alkaryl which can be substituted or unsubstituted; and R2 represents CH3-CO-, CF3-CO-, CH2CICO-, CHCI2-CO-, CCI3-CO-, CH3O-CO-CO-, CH3O-CO-, CH3CH2O-CO-, CH3CH2O-CO-CO, phenyl-CO-, or meta-CH3COO-phenyl- CO- or -S02R'; wherein R' can be selected from hydrogen, straight chain or branched alkyl, aryl, aralkyl, alkaryl, heteroalkyl, heteroaryl and like which can be substituted or unsubstituted.