(8Z)-8-ethenyl-N-[(3R)-2-oxoazetidin-3-yl]undeca-8,10-dienamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (8Z)-8-ethenyl-N-[(3R)-2-oxoazetidin-3-yl]undeca-8,10-dienamide
• 化学式: C₁₆H₂₄N₂O₂
• 分子量: 276.37
• InChiKey: ITTXIXYLSBSSFT-KADHNRKRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] AMIDE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS<br/>[FR] DÉRIVÉS D'AMIDE D'INHIBITEURS DE L'AMIDASE ACIDE DE N-ACYLÉTHANOLAMINE À BASE DE LACTAME
  申请人：UNIV CALIFORNIA

  公开号：WO2014144547A2

  公开（公告）日：2014-09-18

  Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein and methods for formulating these compounds as pharmaceutical compositions which include these compounds. Also described herein are methods of inhibiting NAAA in order to sustain the levels of palmitoylethanolamide (PEA) and other N-acylethanolamines (NAE) that are substrates for NAAA, in conditions characterized by reduced concentrations of NAE. Also, described here are methods of treating and ameliorating pain, inflammation, inflammatory diseases, and other disorders in which modulation of fatty acid ethanolamides is clinically or therapeutically relevant or in which decreased levels of NAE are associated with the disorder.