1-(2-Propan-2-yl-6-azaspiro[3.4]octan-6-yl)prop-2-en-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(2-Propan-2-yl-6-azaspiro[3.4]octan-6-yl)prop-2-en-1-one
• 英文别名: 1-(2-propan-2-yl-6-azaspiro[3.4]octan-6-yl)prop-2-en-1-one
• 化学式: C₁₃H₂₁NO
• 分子量: 207.31
• InChiKey: GIERTUSCHXRCII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] BENZIMIDAZOLE COMPOUNDS AS KINASE INHIBITORS<br/>[FR] COMPOSÉS DE BENZIMIDAZOLE UTILISÉS EN TANT QU'INHIBITEURS DE KINASES
  申请人：GB005 INC

  公开号：WO2019040512A1

  公开（公告）日：2019-02-28

  The present invention relates to a novel family of covalent kinases inhibitors. Compounds of this class have been found to have inhibitory activity against members of the TEC kinase family, particularly RLK (TXK). The present invention is directed to a compound of Formula (I) or pharmaceutically acceptable salt, solvate, solvates of salt, stereoisomer, tautomer, isotope, prodrug, complex or biologically active metabolite thereof, for use in therapy.

  本发明涉及一类新型的共价激酶抑制剂家族。已发现该类化合物对TEC激酶家族的成员，特别是RLK（TXK）具有抑制活性。本发明涉及一种化合物，其化学式为（I）或其药用可接受盐、溶剂、盐的溶剂、立体异构体、互变异构体、同位素、前药、复合物或其生物活性代谢物，用于治疗。
• US20140275014A1
  申请人：——

  公开号：US20140275014A1

  公开（公告）日：2014-09-18
• HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20160031872A1

  公开（公告）日：2016-02-04

  The present invention encompasses compounds of the formula (I) wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
• PYRAZOLE COMPOUNDS AS BTK INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20160340339A1

  公开（公告）日：2016-11-24

  The present invention encompasses compounds of the formula (I) wherein the groups R 1 , Cy, and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
• US8940893B2
  申请人：——

  公开号：US8940893B2

  公开（公告）日：2015-01-27