ethyl-malonic acid ethyl ester-phenyl ester | 109129-23-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: ethyl-malonic acid ethyl ester-phenyl ester
• 英文别名: Aethyl-malonsaeure-aethylester-phenylester；1-O-ethyl 3-O-phenyl 2-ethylpropanedioate
• CAS: 109129-23-9
• 化学式: C₁₃H₁₆O₄
• 分子量: 236.268
• InChiKey: GLEKFAQUOISCPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl-malonic acid ethyl ester-phenyl ester 生成 3-ethyl-chroman-2,4-dione
  参考文献：
  名称：

  Zur Chemie des 4-Hydroxy-cumarins

  摘要：

  DOI：

  10.1007/bf00903604
• 作为产物：
  描述：

  苯酚 、 alkaline earth salt of/the/ methylsulfuric acid 在 三氯氧磷 作用下， 生成 ethyl-malonic acid ethyl ester-phenyl ester
  参考文献：
  名称：

  Zur Chemie des 4-Hydroxy-cumarins

  摘要：

  DOI：

  10.1007/bf00903604

文献信息

• Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
  申请人：——

  公开号：US20030065187A1

  公开（公告）日：2003-04-03

  The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or amine moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In additional embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between a nitrogen atom of an acyl hydrazine and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of a nitrogen-containing heteroaromatic, e.g., indole, pyrazole, and indazole, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-oxygen bond between the oxygen atom of an alcohol and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. The present invention also relates to copper-catalyzed methods of forming a carbon-carbon bond between a reactant comprising a nucleophilic carbon atom, e.g., an enolate or malonate anion, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. Importantly, all the methods of the present invention are relatively inexpensive to practice due to the low cost of the copper comprised by the catalysts.

  本发明涉及铜催化的碳-杂原子和碳-碳键形成方法。在某些实施例中，本发明涉及铜催化的方法，用于在酰胺或胺基团的氮原子与芳基、杂原基或乙烯卤代物或磺酸酯的活化碳之间形成碳-氮键。在其他实施例中，本发明涉及铜催化的方法，用于在酰基肼的氮原子与芳基、杂原基或乙烯卤代物或磺酸酯的活化碳之间形成碳-氮键。在另一些实施例中，本发明涉及铜催化的方法，用于在含氮杂环芳烃（例如吲哚、吡唑和吲哌）的氮原子与芳基、杂原基或乙烯卤代物或磺酸酯的活化碳之间形成碳-氮键。在某些实施例中，本发明涉及铜催化的方法，用于在醇的氧原子与芳基、杂原基或乙烯卤代物或磺酸酯的活化碳之间形成碳-氧键。本发明还涉及铜催化的方法，用于在包含亲核碳原子的反应物（例如烯醇酸盐或丙二酸盐负离子）与芳基、杂原基或乙烯卤代物或磺酸酯的活化碳之间形成碳-碳键。重要的是，由于催化剂中铜的低成本，本发明的所有方法都相对廉价。
• Methods for inhibiting protein kinases
  申请人：Guzi J. Timothy

  公开号：US20070082900A1

  公开（公告）日：2007-04-12

  The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim kinases, and tyrosine kinase using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.

  本发明提供了使用吡唑并[1,5-a]嘧啶化合物抑制选自AKT、检查点激酶、极光激酶、Pim激酶和酪氨酸激酶的蛋白激酶的方法，以及使用这些化合物治疗、预防、抑制或改善与蛋白激酶相关的一种或多种疾病的方法。
• Pyrazolopyrimidines as protein kinase inhibitors
  申请人：Paruch Kamil

  公开号：US20070083044A1

  公开（公告）日：2007-04-12

  In its many embodiments, the present invention provides a novel class of amino-substituted pyrazolo[1,5-a]pyrimidine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.

  在本发明的多种实施方式中，提供了一类新颖的氨基取代的吡唑并[1,5-a]嘧啶化合物，作为蛋白质和/或检查点激酶的抑制剂，制备此类化合物的方法，包含一种或多种此类化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及使用此类化合物或药物组合物治疗、预防、抑制或缓解与蛋白质或检查点激酶相关的一种或多种疾病的方法。
• [EN] ONE POT ACYLATION OF AROMATIC AMINES<br/>[FR] ACYLATION MONOTOPE D'AMINES AROMATIQUES
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2013008256A1

  公开（公告）日：2013-01-17

  The present invention provides a cost effective, environmental friendly and efficient, one pot decarboxylative acylation of aromatic/heteroaromatic primary /secondary amine using diethyl malonate (DEM) to obtain corresponding homologated amides in good yield with a high degree of purity.

  本发明提供了一种经济、环保且高效的方法，使用乙酸二乙酯（DEM）对芳香/杂环原/次要胺进行一锅脱羧酰化反应，以获得相应的同系物酰胺，产率高且纯度高。
• Bisarylimidazolyl fatty acid amide hydrolase inhibitors
  申请人：——

  公开号：US20020188009A1

  公开（公告）日：2002-12-12

  The present invention relates to bisarylimidazolyl derivatives and pharmaceutical compositions comprising said compounds inhibiting fatty acid amide hydrolase and useful for the treatment of pain, particularly neuropathic pain, psychomotor disorder, hypertension, cardiovascular disease, eating disorder, nausea, AIDS-related complex, glaucoma, inflammation, psoriasis or multiple sclerosis, and other conditions the treatment of which can be effected by inhibiting fatty acid amide hydrolase.

  本发明涉及双芳基咪唑基衍生物和含有该类化合物的药物组合物，该组合物能抑制脂肪酸酰胺水解酶，适用于治疗疼痛，特别是神经病性疼痛、精神运动障碍、高血压、心血管疾病、进食障碍、恶心、艾滋病相关综合症、青光眼、炎症、牛皮癣或多发性硬化等疾病，以及其他通过抑制脂肪酸酰胺水解酶可治疗的疾病。