(2S,3S,4E,6S,7R,10R)-7,10-dihydroxy-3,7-dimethyl-2-[(2E,4E,6R)-6-methyl-7-[methyl(propyl)carbamoyl]oxyhepta-2,4-dien-2-yl]-12-oxo-1-oxacyclododec-4-en-6-yl 4-cycloheptylpiperazine-1-carboxylate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: (2S,3S,4E,6S,7R,10R)-7,10-dihydroxy-3,7-dimethyl-2-[(2E,4E,6R)-6-methyl-7-[methyl(propyl)carbamoyl]oxyhepta-2,4-dien-2-yl]-12-oxo-1-oxacyclododec-4-en-6-yl 4-cycloheptylpiperazine-1-carboxylate
• 英文别名: [(2S,3S,4E,6S,7R,10R)-7,10-dihydroxy-3,7-dimethyl-2-[(2E,4E,6R)-6-methyl-7-[methyl(propyl)carbamoyl]oxyhepta-2,4-dien-2-yl]-12-oxo-1-oxacyclododec-4-en-6-yl] 4-cycloheptylpiperazine-1-carboxylate
• 化学式: C₃₈H₆₃N₃O₈
• 分子量: 689.934
• InChiKey: CQNXLNFSUMILTF-GEWPGYQASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  49
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• US20140275010A1
  申请人：——

  公开号：US20140275010A1

  公开（公告）日：2014-09-18
• CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE
  申请人：EISAI R&D MANAGEMENT CO., LTD.

  公开号：US20210163456A1

  公开（公告）日：2021-06-03

  The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
• [EN] CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE<br/>[FR] CERTAINS COMPOSÉS DE PLADIÉNOLIDE ET PROCÉDÉS D'UTILISATION
  申请人：KEANEY GREGG F

  公开号：WO2019199667A2

  公开（公告）日：2019-10-17

  The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.