3,4-Bis(hydroxymethyl)-5-methoxybenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-Bis(hydroxymethyl)-5-methoxybenzoic acid
• 英文别名: 3,4-bis(hydroxymethyl)-5-methoxybenzoic acid
• 化学式: C₁₀H₁₂O₅
• 分子量: 212.2
• InChiKey: WTVBTJJPOMPKOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Method of preparing ATG's analogue, and the application of ATG and it's analogue
  申请人：Longhua Hospital Shanghai University of Traditional Chinese Medicine

  公开号：US20170313667A1

  公开（公告）日：2017-11-02

  The present invention provides the use of ATG in the preparation of a reagent for adjusting the activity of PP2A; and the use of ATG in increasing the activity of PP2A in 293T cells. The present invention also provides the use of the arctigenin in the preparation of the medicine for reducing the proteinuria of the diabetic mice. The present invention also provides the use of the arctigenin in the preparation of the reagent for inhibiting the expression of the NOX4 gene. The present invention also provides analogues of arctigenin and application thereof. The present invention provides a novel use of ATG for modulating PP2A activity, and ATG can also significantly reduce proteinuria in diabetic mice. At the same time, arctigenin could significantly inhibit the expression of NOX4 in STZ-eNOS −/− mice glomeruli. The ATG analogues of the present invention are more effective than the native ATG.

  本发明提供了在制备用于调节PP2A活性的试剂时使用ATG的方法；以及在增加293T细胞中PP2A活性时使用ATG的方法。本发明还提供了在制备用于降低糖尿病小鼠蛋白尿的药物中使用牛蒡苷的方法。本发明还提供了在制备抑制NOX4基因表达的试剂中使用牛蒡苷的方法。本发明还提供了牛蒡苷的类似物及其应用。本发明提供了ATG用于调节PP2A活性的新用途，ATG还可以显著减少糖尿病小鼠的蛋白尿。同时，牛蒡苷可以显著抑制STZ-eNOS−/−小鼠的肾小球中NOX4的表达。本发明的ATG类似物比原生ATG更有效。
• US20140275088A1
  申请人：——

  公开号：US20140275088A1

  公开（公告）日：2014-09-18
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  申请人：——

  公开号：US9873661B2

  公开（公告）日：2018-01-23
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  申请人：——

  公开号：US9994533B2

  公开（公告）日：2018-06-12