1-(2-Propan-2-yl-6-azaspiro[3.4]octan-6-yl)but-2-yn-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(2-Propan-2-yl-6-azaspiro[3.4]octan-6-yl)but-2-yn-1-one
• 英文别名: 1-(2-propan-2-yl-6-azaspiro[3.4]octan-6-yl)but-2-yn-1-one
• 化学式: C₁₄H₂₁NO
• 分子量: 219.32
• InChiKey: BQYOUHQIDJMKLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• US20140275014A1
  申请人：——

  公开号：US20140275014A1

  公开（公告）日：2014-09-18
• PYRAZOLE COMPOUNDS AS BTK INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20160340339A1

  公开（公告）日：2016-11-24

  The present invention encompasses compounds of the formula (I) wherein the groups R 1 , Cy, and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
• HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20180086748A1

  公开（公告）日：2018-03-29

  The present invention encompasses compounds of the formula (I) wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
• US9828364B2
  申请人：——

  公开号：US9828364B2

  公开（公告）日：2017-11-28