[4-[(2S)-2-[4-(2,2-dimethylpropanoyloxy)-1,3-thiazol-2-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]phenyl]sulfamic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-[(2S)-2-[4-(2,2-dimethylpropanoyloxy)-1,3-thiazol-2-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]phenyl]sulfamic acid
• 化学式: C₂₁H₂₉N₃O₇S₂
• 分子量: 499.6
• InChiKey: XAMSWURHUNEZDT-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  181
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• Tie-2 activators targeting the Schlemm's canal
  申请人：EyePoint Pharmaceuticals, Inc.

  公开号：US11253502B2

  公开（公告）日：2022-02-22

  Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for eye conditions, for example, intraocular pressure, ocular hypertension, and glaucoma.

  本文公开了对激活 Tie-2 和抑制 HPTP-beta 有效的化合物。这些化合物可有效治疗眼部疾病，如眼内压、眼压过高和青光眼。
• US20140275103A1
  申请人：——

  公开号：US20140275103A1

  公开（公告）日：2014-09-18
• TIE-2 ACTIVATORS TARGETING THE SCHLEMM'S CANAL
  申请人：Aerpio Pharmaceuticals, Inc.

  公开号：US20200338048A1

  公开（公告）日：2020-10-29

  Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for eye conditions, for example, intraocular pressure, ocular hypertension, and glaucoma.
• COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES
  申请人：Aerpio Pharmaceuticals, Inc.

  公开号：US20200361926A1

  公开（公告）日：2020-11-19

  Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.
• US9440963B2
  申请人：——

  公开号：US9440963B2

  公开（公告）日：2016-09-13