(S)-2-(methylsuccinimido)benzoic acid | 221183-23-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-2-(methylsuccinimido)benzoic acid
• 英文别名: 2-[(3S)-3-methyl-2,5-dioxopyrrolidin-1-yl]benzoic acid
• CAS: 221183-23-9
• 化学式: C₁₂H₁₁NO₄
• 分子量: 233.224
• InChiKey: OMRMFMYVQMSRLZ-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (S)-2-(methylsuccinimido)benzoic acid 、 (S)-3-hydroxymethyl-N-(3-phenyl)propylpiperidine 在 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以78.9%的产率得到2-((S)-3-Methyl-2,5-dioxo-pyrrolidin-1-yl)-benzoic acid (S)-1-(3-phenyl-propyl)-piperidin-3-ylmethyl ester
  参考文献：
  名称：

  Structure–activity studies with ring E analogues of methyllycaconitine. Synthesis and evaluation of enantiopure isomers of selective antagonist at the α3 nicotinic receptor

  摘要：

  The four diastereomers 4a-d of methyllycaconitine (MLA) analogue 3 (R = (CH2)(3)Ph, R' = CH3) have been synthesized in enantiomerically pure form by coupling both (S)- and (R)-2-(methylsuccinimido)benzoic acid (5a and 5b) with both (S)- and (R)-3-hydroxymethyl-N-(3-phenyl) propylpiperidine (6a and 6b) using TBTU. These compounds were assayed for potency as nicotinic acetylcholine receptor (nAChRs) antagonist. All the four diastereomers showed the same potency at both the alpha3 and alpha7 receptors as racemic compound 3. This indicates that the binding at nicotine acetylcholine receptors (nAchRs) is probably non-stereospecific. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

  DOI：

  10.1016/s0223-5234(02)01353-3
• 作为产物：
  描述：

  (S)-(-)-甲基丁二酸 在 乙酰氯 作用下， 145.0 ℃ 、13.33 Pa 条件下， 反应 6.0h， 生成 (S)-2-(methylsuccinimido)benzoic acid
  参考文献：
  名称：

  Structure–activity studies with ring E analogues of methyllycaconitine. Synthesis and evaluation of enantiopure isomers of selective antagonist at the α3 nicotinic receptor

  摘要：

  The four diastereomers 4a-d of methyllycaconitine (MLA) analogue 3 (R = (CH2)(3)Ph, R' = CH3) have been synthesized in enantiomerically pure form by coupling both (S)- and (R)-2-(methylsuccinimido)benzoic acid (5a and 5b) with both (S)- and (R)-3-hydroxymethyl-N-(3-phenyl) propylpiperidine (6a and 6b) using TBTU. These compounds were assayed for potency as nicotinic acetylcholine receptor (nAChRs) antagonist. All the four diastereomers showed the same potency at both the alpha3 and alpha7 receptors as racemic compound 3. This indicates that the binding at nicotine acetylcholine receptors (nAchRs) is probably non-stereospecific. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

  DOI：

  10.1016/s0223-5234(02)01353-3

文献信息

• Structure–activity studies with ring E analogues of methyllycaconitine. Synthesis and evaluation of enantiopure isomers of selective antagonist at the α3 nicotinic receptor
  作者：K.A Ismail、S.C Bergmeier

  DOI：10.1016/s0223-5234(02)01353-3

  日期：2002.6

  The four diastereomers 4a-d of methyllycaconitine (MLA) analogue 3 (R = (CH2)(3)Ph, R' = CH3) have been synthesized in enantiomerically pure form by coupling both (S)- and (R)-2-(methylsuccinimido)benzoic acid (5a and 5b) with both (S)- and (R)-3-hydroxymethyl-N-(3-phenyl) propylpiperidine (6a and 6b) using TBTU. These compounds were assayed for potency as nicotinic acetylcholine receptor (nAChRs) antagonist. All the four diastereomers showed the same potency at both the alpha3 and alpha7 receptors as racemic compound 3. This indicates that the binding at nicotine acetylcholine receptors (nAchRs) is probably non-stereospecific. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.