6-ethoxy-4-[(2-methoxy-4-methylphenyl)methyl]-5-methyl-3,5-dihydro-2H-pyrazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-ethoxy-4-[(2-methoxy-4-methylphenyl)methyl]-5-methyl-3,5-dihydro-2H-pyrazine
• 化学式: C₁₆H₂₄N₂O₂
• 分子量: 276.37
• InChiKey: DKVOPFBSRDKIRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• US20140275097A1
  申请人：——

  公开号：US20140275097A1

  公开（公告）日：2014-09-18
• NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
  申请人：Hoveyda Hamid

  公开号：US20170029429A1

  公开（公告）日：2017-02-02

  The present invention relates to novel compounds of Formula I and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines using N-sp3 protective groups. The invention also provides intermediates for use in the synthesis of compounds of Formula I.
• US9475814B2
  申请人：——

  公开号：US9475814B2

  公开（公告）日：2016-10-25