6-Methyl-2,3-dihydro-1,2-benzoxazole

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 6-Methyl-2,3-dihydro-1,2-benzoxazole
• 英文别名: 6-methyl-2,3-dihydro-1,2-benzoxazole
• 化学式: C₈H₉NO
• 分子量: 135.16
• InChiKey: PONWQYRPSFVIKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• ACC2 INHIBITORS
  申请人：Shionogi & Co., Ltd.

  公开号：EP3670496A2

  公开（公告）日：2020-06-24

  The object of the present invention is to provide novel compounds having ACC2 inhibiting activity. In addition, the object of the present invention is to provide a pharmaceutical composition comprising the compound. A compound of formula (I): wherein R1 is substituted or unsubstituted fused aromatic heterocyclyl etc., ring A is substituted or unsubstituted non-aromatic carbocycle etc., -L1- is -O-(CR6R7)m- etc., -L2- is -O-(CR6R7)n- etc., each R6 and R7 are independently hydrogen, halogen etc., R2 is substituted or unsubstituted alkyl, R3 is hydrogen or substituted or unsubstituted alkyl, R4 is substituted or unsubstituted alkylcarbonyl etc..

  本发明的目的是提供具有 ACC2 抑制活性的新型化合物。此外，本发明的目的是提供一种包含该化合物的药物组合物。 式(I)的化合物： 其中 R1 是取代或未取代的融合芳香杂环等、 环 A 是取代或未取代的非芳香族碳环等、 -L1-是-O-(CR6R7)m-等、 -L2-是-O-(CR6R7)n-等、 每个 R6 和 R7 独立地是氢、卤素等、 R2 是取代或未取代的烷基、 R3 是氢或取代或未取代的烷基、 R4 是取代或未取代的烷基羰基等。
• NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES
  申请人：Rhizen Pharmaceuticals SA

  公开号：US20210401840A1

  公开（公告）日：2021-12-30

  The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.
• [EN] SUBSTITUTED BENZOXAZOLES AND METHODS OF USE THEREOF<br/>[FR] BENZOXAZOLES SUBSTITUÉS ET LEURS PROCÉDÉS D'UTILISATION
  申请人：GENENTECH INC

  公开号：WO2014144545A2

  公开（公告）日：2014-09-18

  The invention provides compounds having the general formula (I): and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.