1,3,4-Tritert-butylpyrrole-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1,3,4-Tritert-butylpyrrole-2,5-dione
• 英文别名: 1,3,4-tritert-butylpyrrole-2,5-dione
• 化学式: C₁₆H₂₇NO₂
• 分子量: 265.39
• InChiKey: NSNJFNNTLIKXOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• US20140275006A1
  申请人：——

  公开号：US20140275006A1

  公开（公告）日：2014-09-18
• TAXANE-LIPID-POLYSACCHARIDE DUAL CONJUGATES, PREPARATION METHODS THEREOF AND USES THEREOF
  申请人：Santolecan Pharmaceuticals LLC

  公开号：US20210228530A1

  公开（公告）日：2021-07-29

  The present invention pertains to a group of taxane-lipid-polysaccharide dual conjugates of the Formula I, a process for the preparation thereof, uses thereof, and pharmaceutical compositions comprising the same. The invention also relates to a series of intermediates for the preparation of taxane-lipid-polysaccharide dual conjugates, a process for their preparation, and their use as drug delivery vehicles.
• TETRAZINES FOR HIGH CLICK CONJUGATION YIELD IN VIVO AND HIGH CLICK RELEASE YIELD
  申请人：Tagworks Pharmaceuticals B.V.

  公开号：US20210299286A1

  公开（公告）日：2021-09-30

  Disclosed herein are tetrazines substituted with groups that result in a high click conjugation yield in vivo and high click release yields. In one aspect, the invention relates to kits having the tetrazines and a dienophile, preferably a trans-cyclooctene. In another aspect, the kits of the invention are for use as a medicament.
• COMPOUNDS COMPRISING A LINKER FOR INCREASING TRANSCYCLOOCTENE STABILITY
  申请人：Tagworks Pharmaceuticals B.V.

  公开号：US20210308207A1

  公开（公告）日：2021-10-07

  Disclosed are compounds having a linker for increasing trans-cyclooctene stability. The linker of the invention is a three-arm linker. In some embodiments, one arm of the linker is attached to a trans-cyclooctene moiety, another arm is attached to a compound selected from the group consisting of antibodies, proteins, peptides, and peptoids, and the third arm extends into the solution.
• US9522914B2
  申请人：——

  公开号：US9522914B2

  公开（公告）日：2016-12-20