ethyl 3-amino-4-cyano-2-methyl-9H-fluorene-1-carboxylate | 1393333-82-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: ethyl 3-amino-4-cyano-2-methyl-9H-fluorene-1-carboxylate
• CAS: 1393333-82-8
• 化学式: C₁₈H₁₆N₂O₂
• 分子量: 292.337
• InChiKey: DSTQMKIXTNPHBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-环己基羟基胺盐酸盐 、 ethyl 3-nitrobut-2-enoate 在 三乙胺 、 盐酸 作用下， 以 乙腈 、 水 为溶剂， 反应 18.0h， 以70%的产率得到ethyl 3-amino-4-cyano-2-methyl-9H-fluorene-1-carboxylate
  参考文献：
  名称：

  β-Nitroacrylates as key starting materials for the one-pot synthesis of densely functionalized penta-substituted anilines

  摘要：

  The reaction of ylidene malononitriles with beta-nitroacrylates, in Et3N/MeCN, affords the one-pot synthesis of a new class of penta-substituted, densely functionalized anilines in satisfactory to good overall yields. The method represents a very important improvement of the recent strategy for the preparation of anilines from conjugated nitroalkenes. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.07.065

文献信息

• β-Nitroacrylates as key starting materials for the one-pot synthesis of densely functionalized penta-substituted anilines
  作者：Serena Gabrielli、Alessandro Palmieri、Deepak S. Panmand、Daniela Lanari、Luigi Vaccaro、Roberto Ballini

  DOI：10.1016/j.tet.2012.07.065

  日期：2012.9

  The reaction of ylidene malononitriles with beta-nitroacrylates, in Et3N/MeCN, affords the one-pot synthesis of a new class of penta-substituted, densely functionalized anilines in satisfactory to good overall yields. The method represents a very important improvement of the recent strategy for the preparation of anilines from conjugated nitroalkenes. (C) 2012 Elsevier Ltd. All rights reserved.