2-[1-[[3-(3,3-Difluoropyrrolidin-1-yl)phenyl]methyl]-6-[(5-methylpyridin-2-yl)methoxy]benzimidazol-2-yl]cyclohexane-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-[1-[[3-(3,3-Difluoropyrrolidin-1-yl)phenyl]methyl]-6-[(5-methylpyridin-2-yl)methoxy]benzimidazol-2-yl]cyclohexane-1-carboxylic acid
• 英文别名: 2-[1-[[3-(3,3-difluoropyrrolidin-1-yl)phenyl]methyl]-6-[(5-methylpyridin-2-yl)methoxy]benzimidazol-2-yl]cyclohexane-1-carboxylic acid
• 化学式: C₃₂H₃₄F₂N₄O₃
• 分子量: 560.6
• InChiKey: KRHWERAYJHVNGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  41
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  80.5
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• 1,2,6-SUBSTITUTED BENZIMIDAZOLES AS FLAP MODULATORS
  申请人：CHAI Wenying

  公开号：US20160039790A1

  公开（公告）日：2016-02-11

  The present invention relates to compounds of Formula (I), and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein X 1 , X 1 ′, X 1 ″, R 1 , R 2 and R 3 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

  本发明涉及公式（I）的化合物及其溶剂化物、水合物和药学上可接受的盐，其中X1、X1'、X1"、R1、R2和R3的定义如本文所述，可用作FLAP调节剂。本发明还涉及包括公式（I）化合物的制药组合物。制备和使用公式（I）化合物的方法也属于本发明的范围。
• US9695149B2
  申请人：——

  公开号：US9695149B2

  公开（公告）日：2017-07-04
• [EN] 1,2,6-SUBSTITUTED BENZIMIDAZOLES AS FLAP MODULATORS<br/>[FR] BENZIMIDAZOLES 1,2,6-SUBSTITUÉS COMME MODULATEURS DE FLAP
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2014151380A1

  公开（公告）日：2014-09-25

  The present invention relates to compounds of Formula (I), and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein X1, X1', X1'', R1, R2 and R3 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.