6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-N,2-N,4-N-tris(prop-2-enyl)pyrimido[5,4-d]pyrimidine-2,4,8-triamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-N,2-N,4-N-tris(prop-2-enyl)pyrimido[5,4-d]pyrimidine-2,4,8-triamine
• 化学式: C₃₂H₃₅F₂N₉
• 分子量: 583.7
• InChiKey: PRCYMVNFBGIDPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  43
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  99.3
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• NOVEL BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME
  申请人：GALLEON PHARMACEUTICALS, INC.

  公开号：US20160046635A1

  公开（公告）日：2016-02-18

  The present invention includes pyrimido[5,4-d]pyrimidines that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound of the invention.

  本发明涉及对呼吸控制疾病或障碍的预防和/或治疗有用的嘧啶并[5,4-d]嘧啶。本发明还包括一种预防和/或治疗受访者的呼吸系统疾病或障碍的方法，包括向受访者施用本发明中至少一种化合物的治疗有效量。本发明还包括一种预防不稳定或稳定受访者呼吸节律的方法，包括向受访者施用本发明中至少一种化合物的治疗有效量。
• US9643971B2
  申请人：——

  公开号：US9643971B2

  公开（公告）日：2017-05-09
• [EN] NOVEL BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME<br/>[FR] NOUVEAUX COMPOSÉS DE MODULATION DU CONTRÔLE DE LA RESPIRATION ET LEURS PROCÉDÉS D'UTILISATION
  申请人：GALLEON PHARMACEUTICALS INC

  公开号：WO2014151462A1

  公开（公告）日：2014-09-25

  The present invention includes pyrimido[5,4-d]pyrimidines that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of the invention.