Tert-butyl 7-(5-amino-2-fluorophenyl)-7-methyl-9-[(2-methylpropan-2-yl)oxycarbonylamino]-5,5-dioxo-5lambda6-thia-2,8-diazaspiro[3.5]non-8-ene-2-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Tert-butyl 7-(5-amino-2-fluorophenyl)-7-methyl-9-[(2-methylpropan-2-yl)oxycarbonylamino]-5,5-dioxo-5lambda6-thia-2,8-diazaspiro[3.5]non-8-ene-2-carboxylate
• 英文别名: tert-butyl 7-(5-amino-2-fluorophenyl)-7-methyl-9-[(2-methylpropan-2-yl)oxycarbonylamino]-5,5-dioxo-5λ6-thia-2,8-diazaspiro[3.5]non-8-ene-2-carboxylate
• 化学式: C₂₃H₃₃FN₄O₆S
• 分子量: 512.6
• InChiKey: GMZSMMODGVCMGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  149
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] C2-AZASPIRO IMINOTHIAZINE DIOXIDES AS BACE INHIBITORS<br/>[FR] DIOXYDES C2-AZASPIRO IMINOTHIAZINES EN TANT QU'INHIBITEURS DE BACE
  申请人：MERCK SHARP & DOHME

  公开号：WO2014150344A1

  公开（公告）日：2014-09-25

  In its many embodiments, the present invention provides certain C2-azaspirosubstituted iminothiazine dioxide compounds. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.

  在其多种实施方式中，本发明提供了某些C2-氮杂螺取代亚噁唑二氧化物化合物。本发明的新化合物可用作BACE抑制剂和/或用于治疗和预防与之相关的各种病理。还公开了包括一种或多种这样的化合物（单独和与一种或多种其他活性剂的组合）的药物组合物，以及其制备和使用的方法，包括可能用于治疗阿尔茨海默病。
• C2-AZASPIRO IMINOTHIAZINE DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
  申请人：GILBERT Eric J.

  公开号：US20160016975A1

  公开（公告）日：2016-01-21

  In its many embodiments, the present invention provides certain C2-azaspiro substituted iminothiazine dioxide compounds. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.

  在其多种实施方式中，本发明提供了某些C2-氮杂螺环取代的亚硫酰亚胺化合物。该发明的新型化合物可用作BACE抑制剂和/或用于治疗和预防与之相关的各种病理学。还公开了包含一个或多个这样的化合物（单独和与一个或多个其他活性剂的组合）的制药组合物，以及其制备和使用的方法，包括可能用于治疗阿尔茨海默病。
• C2-AZASPIRO IMINOTHIAZINE DIOXIDES AS BACE INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2968353A1

  公开（公告）日：2016-01-20
• US9453034B2
  申请人：——

  公开号：US9453034B2

  公开（公告）日：2016-09-27