(2,6-Dichloro-phenyl)-((S)-4-methyl-4,5-dihydro-1H-imidazol-2-yl)-amine | 788772-71-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,6-Dichloro-phenyl)-((S)-4-methyl-4,5-dihydro-1H-imidazol-2-yl)-amine
• 英文别名: (4S)-N-(2,6-dichlorophenyl)-4-methyl-4,5-dihydro-1H-imidazol-2-amine
• CAS: 788772-71-4
• 化学式: C₁₀H₁₁Cl₂N₃
• 分子量: 244.123
• InChiKey: ITKQNORKNISIMB-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  36.4
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  S-methyl-(2,6-dichlorophenyl)isothiouronium iodide 、 (S)-propane-1,2-diamine dihydrochloride 在 三乙胺 作用下， 以 丙醇 为溶剂， 反应 12.0h， 以89%的产率得到(2,6-Dichloro-phenyl)-((S)-4-methyl-4,5-dihydro-1H-imidazol-2-yl)-amine
  参考文献：
  名称：

  Optically active derivatives of imidazolines. .alpha.-Adrenergic blocking properties

  摘要：

  The synthesis and alpha-adrenergic blocking activity of a series of optically active 2,4-disubstituted imidazolines are presented. The substituted analogues of naphazoline, tolazoline, and clonidine possess moderate alpha-adrenergic blocking activity with -log KB values in the range from 4.77 to 6.57. The differences between the alpha-adrenergic blocking activity of the stereoisomers of the 2,4-disubstituted imidazolines were small or insignificant in the rabbit aortic tissue preparations.

  DOI：

  10.1021/jm00185a017

文献信息

• Optically active derivatives of imidazolines. .alpha.-Adrenergic blocking properties
  作者：Fu-Lian Hsu、Akihiko Hamada、Mark E. Booher、H. Fuder、P. N. Patil、Duane D. Miller

  DOI：10.1021/jm00185a017

  日期：1980.11

  The synthesis and alpha-adrenergic blocking activity of a series of optically active 2,4-disubstituted imidazolines are presented. The substituted analogues of naphazoline, tolazoline, and clonidine possess moderate alpha-adrenergic blocking activity with -log KB values in the range from 4.77 to 6.57. The differences between the alpha-adrenergic blocking activity of the stereoisomers of the 2,4-disubstituted imidazolines were small or insignificant in the rabbit aortic tissue preparations.