ethyl 2-(benzyloxy)cyclopropane-1-carboxylate | 6639-51-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-(benzyloxy)cyclopropane-1-carboxylate
• 英文别名: Aethyl-cis-trans-2-benzyloxy-cyclopropancarboxylat；Ethyl 2-(benzyloxy)cyclopropanecarboxylate；ethyl 2-phenylmethoxycyclopropane-1-carboxylate
• CAS: 6639-51-6
• 化学式: C₁₃H₁₆O₃
• 分子量: 220.268
• InChiKey: FCQGKIBPYZALNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 2-(benzyloxy)cyclopropane-1-carboxylate 在 甲醇 、 水 、 lithium hydroxide 作用下， 生成 2-(benzyloxy)cyclopropane-1-carboxylic acid
  参考文献：
  名称：

  [EN] PYRAOLO- AND TRIAZOLO-AZINONE COMPOUNDS AND THEIR USES
  [FR] COMPOSÉS DE PYRAOLO-AZINONE ET DE TRIAZOLO-AZINONE ET LEURS UTILISATIONS

  摘要：

  The specification relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions containing them and to their use in the treatment or prevention of diseases and conditions including nervous system diseases or conditions.

  公开号：

  WO2023099648A1
• 作为产物：
  描述：

  重氮乙酸乙酯 、 乙烯氧基甲基-苯 在 dirhodium tetraacetate 作用下， 以 二氯甲烷 为溶剂， 以73.8 %的产率得到ethyl 2-(benzyloxy)cyclopropane-1-carboxylate
  参考文献：
  名称：

  [EN] PYRAOLO- AND TRIAZOLO-AZINONE COMPOUNDS AND THEIR USES
  [FR] COMPOSÉS DE PYRAOLO-AZINONE ET DE TRIAZOLO-AZINONE ET LEURS UTILISATIONS

  摘要：

  The specification relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions containing them and to their use in the treatment or prevention of diseases and conditions including nervous system diseases or conditions.

  公开号：

  WO2023099648A1

文献信息

• [EN] MACROLIDE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME<br/>[FR] COMPOSÉS MACROLIDES ET PROCÉDÉS DE FABRICATION ET D'UTILISATION DE CEUX-CI
  申请人：RIB X PHARMACEUTICALS INC

  公开号：WO2008106225A1

  公开（公告）日：2008-09-04

  [EN] The present invention provides cycloalkyl containing macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
  [FR] L'invention concerne des composés macrocycliques contenant un cycloalkyle utile en tant qu'agents thérapeutiques. Plus particulièrement, ces composés sont utiles en tant qu'agents anti-infectieux, anti-prolifération, anti-inflammatoires et procinétiques.
• [EN] MITOFUSIN ACTIVATORS HAVING AN ENDOCYCLIC-BONDED CARBONYL GROUP AND METHODS FOR USE THEREOF<br/>[FR] ACTIVATEURS DE MITOFUSINE COMPORTANT UN GROUPE CARBONYLE LIÉ ENDOCYCLIQUE ET LEURS MÉTHODES D'UTILISATION
  申请人：[en]DORN II, Gerald W.

  公开号：WO2023196340A1

  公开（公告）日：2023-10-12

  Compositions capable of promoting mitofusin activation may include a mitofusin activator having a structure represented by (I) any stereoisomer thereof, or any pharmaceutically acceptable salt thereof. G is N or CH, and A is an optionally substituted 5- or 6-membered cycloalkyl or heterocycloalkyl ring. X is (CH2)3, OCH2CH2, CH2OCH2, CH2CH2O, Cyc, CH2Cyc, NR1(CH2)3, NR1OCH2CH2, NR1CH2OCH2, NR1CH2CH2O, or NR1Y, R1is H or C1-C6alkyl, and Cyc is 1,2-cyclopropyl, 1,2-cyclobutyl, 1,3-cyclobutyl, 1,2-cyclopentyl, 1,3-cyclopentyl, 1,2-cyclohexyl, 1,3-cyclohexyl, or 1,4-cyclohexyl. Z is (CH2)nor (CH2)n1O(CH2)n2. R2is an optionally substituted aryl or heteroaryl group. Variable n is an integer ranging from 1 to 5, variable n1is an integer ranging from 0 to 4, variable n2is an integer ranging from 0 to 4, and n1+n2=n-1.
• [EN] PYRAOLO- AND TRIAZOLO-AZINONE COMPOUNDS AND THEIR USES<br/>[FR] COMPOSÉS DE PYRAOLO-AZINONE ET DE TRIAZOLO-AZINONE ET LEURS UTILISATIONS
  申请人：[en]ASTRAZENECA AB

  公开号：WO2023099648A1

  公开（公告）日：2023-06-08

  The specification relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions containing them and to their use in the treatment or prevention of diseases and conditions including nervous system diseases or conditions.