(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;2-(2-methyl-5-nitroimidazol-1-yl)ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;2-(2-methyl-5-nitroimidazol-1-yl)ethanol
• 化学式: C22H28N6O8S
• 分子量: 536.6
• InChiKey: CWESHVJKQKDEBE-YWUHCJSESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.12
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  242
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• COMBINATIONS OF N-ACETYL CYSTEINE DERIVATIVES AND CRANBERRY POLYPHENOLS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING PERIODONTAL DISEASES AND PERI-IMPLATITIS
  申请人：Dentalmed Pharm Holding Ltd.

  公开号：EP2976061B1

  公开（公告）日：2019-10-16
• TREATING AND DETECTING DYSBIOSIS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20200332344A1

  公开（公告）日：2020-10-22

  Provided herein are, inter alia, methods, compositions, and systems, for detecting and treating dysbiosis such as nasal and sinus dysbiosis. In aspects, included herein are methods, compositions, and systems for detecting asthma, chronic rhinosinusitis, and infections (such as rhinovirus infections), and methods of treating such disorders. Also provided are methods, compositions, and systems for detecting whether a subject has an increased risk of asthma, an infection, asthma exacerbation, chronic rhinosinusitis, or nasal polyposis, as well as methods of treating at-risk subjects. Methods, compositions, and systems for monitoring subjects diagnosted as having a disease or risk as disclosed herein are also included.
• [EN] COMBINATIONS OF N-ACETYL CYSTEINE DERIVATIVES AND CRANBERRY POLYPHENOLS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING PERIODONTAL DISEASES AND PERI-IMPLATITIS<br/>[FR] COMBINAISON DE DÉRIVÉS DE N-ACÉTYLCYSTÉINE ET DE POLYPHÉNOLS DE CANNEBERGE DANS DES COMPOSITIONS ET DES PROCÉDÉS POUR PRÉVENIR ET TRAITER DES MALADIES PARODONTIQUES ET UNE PÉRI-IMPLANTITE
  申请人：DENTALMED PHARM HOLDING LTD

  公开号：WO2014147613A1

  公开（公告）日：2014-09-25

  The present invention relates to combined compositions comprising a combination of N-acetyl cysteine (NAC), or any derivatives thereof, and polyphenols, specifically cranberry polyphenols. The invention further provides methods and uses of said combined compositions for treating and preventing periodontal diseases, specifically gingivitis, periodontitis and peri-implantitis.