4-[3-Cyano-2-(4-phenoxyanilino)pyrazolo[1,5-a]pyrimidin-6-yl]-2-hydroxy-3-nitrobenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[3-Cyano-2-(4-phenoxyanilino)pyrazolo[1,5-a]pyrimidin-6-yl]-2-hydroxy-3-nitrobenzoic acid
• 英文别名: 4-[3-cyano-2-(4-phenoxyanilino)pyrazolo[1,5-a]pyrimidin-6-yl]-2-hydroxy-3-nitrobenzoic acid
• 化学式: C26H16N6O6
• 分子量: 508.4
• InChiKey: XXGBVTLBNNAACH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  179
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• INHIBITORS OF LEUKOTRIENE A4 HYDROLASE
  申请人：Celtaxsys, Inc.

  公开号：US20160068534A1

  公开（公告）日：2016-03-10

  The present invention is directed to compounds encompassed by the Formula (I), pharmaceutical compositions thereof, methods for inhibiting LTA-4 hydrolase, and methods for the treatment of a disease and disorder which is ameliorated by the inhibition of LTA4 h activity. Non-limiting examples of such diseases and conditions include inflammatory and autoimmune diseases and disorders.

  本发明涉及公式（I）所包含的化合物，其制药组合物，抑制LTA-4水解酶的方法，以及通过抑制LTA4h活性治疗疾病和疾病的方法和治疗疾病和疾病的方法。此类疾病和状况的非限制性示例包括炎症和自身免疫性疾病和疾病。
• Inhibitors of leukotriene A4 hydrolase
  申请人：CELTAXSYS, INC.

  公开号：US10399986B2

  公开（公告）日：2019-09-03

  The present invention is directed to compounds encompassed by the Formula (I): pharmaceutical compositions thereof, methods for inhibiting LTA-4 hydrolase, and methods for the treatment of a disease and disorder which is ameliorated by the inhibition of LTA4h activity. Non-limiting examples of such diseases and conditions include inflammatory and autoimmune diseases and disorders.

  本发明涉及式 (I) 所包含的化合物： 其药物组合物、抑制LTA-4水解酶的方法，以及治疗通过抑制LTA4h活性而得到改善的疾病和紊乱的方法。此类疾病和病症的非限制性实例包括炎症性和自身免疫性疾病和病症。
• US9777006B2
  申请人：——

  公开号：US9777006B2

  公开（公告）日：2017-10-03
• [EN] INHIBITORS OF LEUKOTRIENE A4 HYDROLASE<br/>[FR] INHIBITEURS DE LA LEUCOTRIÈNE A4 HYDROLASE
  申请人：CELTAXSYS INC

  公开号：WO2014152518A2

  公开（公告）日：2014-09-25

  The present invention is directed to compounds encompassed by the Formula (I), pharmaceutical compositions thereof, methods for inhibiting LTA-4 hydrolase, and methods for the treatment of a disease and disorder which is ameliorated by the inhibition of LTA4h activity. Non-limiting examples of such diseases and conditions include inflammatory and autoimmune diseases and disorders.