1-Ethyl-4-phenylpyridin-1-ium | 106777-10-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-Ethyl-4-phenylpyridin-1-ium
• CAS: 106777-10-0
• 化学式: C13H14N+
• 分子量: 184.26
• InChiKey: RKXWFNKMYXFZTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• DEGRADABLE POLYMERS OF A CYCLIC SILYL ETHER AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：EP3837266A1

  公开（公告）日：2021-06-23
• US6176909B1
  申请人：——

  公开号：US6176909B1

  公开（公告）日：2001-01-23
• [EN] NANOPARTICLE CONJUGATES AND USES THEREOF<br/>[FR] CONJUGUÉS DE NANOPARTICULES ET UTILISATIONS DE CES DERNIERS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2018093864A1

  公开（公告）日：2018-05-24

  The targeted delivery of therapeutic agents to specific cells remains a challenge in drug delivery. Provided herein are nanoparticle-targeting agent conjugates that can be used for the targeted delivery of therapeutic agents to certain cells and target tissues. The conjugates comprise nanoparticles (e.g., metal nanoparticles such as gold nanoparticles) with organic outer shells capable of adsorbing large numbers of therapeutic agents (e.g., small molecule drugs). The nanoparticles are covalently linked to targeting agents (e.g., proteins such as antibodies). The present invention also provides formulations comprising the nanoparticle-targeting agent conjugates, and kits comprising the same. In another aspect, the present invention provides methods of using the conjugates for the delivery of therapeutic agents to cells, and the treatment and/or prevention of diseases (e.g., autoimmune diseases, infectious diseases, proliferative diseases such as cancer). In another aspect, the present invention provides methods of preparing the nanoparticle-targeting agent conjugates described herein.
• [EN] DISCOVERY OF SMALL MOLECULES THAT TARGET THE ANDROGEN RECEPTOR AND USES THEREOF<br/>[FR] DÉCOUVERTE DE PETITES MOLÉCULES CIBLANT LE RÉCEPTEUR DES ANDROGÈNES ET LEURS UTILISATIONS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2019023654A2

  公开（公告）日：2019-01-31

  Provided herein are methods useful for identifying compounds that modulate the activity of an androgen receptor, or variant thereof. In particular, this invention encompasses reagents and strategies for identifying compounds that target specific androgen receptor splice variants, for example, AR-v7, that are important for prostate cancer progression and metastasis, for example in the development of castration-resistant prostate cancer. Also provided herein are specific compounds that modulate the activity of an androgen receptor, or variant thereof, pharmaceutical compositions, and methods of using these compounds and pharmaceutical compositions for modulating the activity of an androgen receptor, or variant thereof in vitro and in vivo.
• [EN] DEGRADABLE POLYMERS OF A CYCLIC SILYL ETHER AND USES THEREOF<br/>[FR] POLYMÈRES DÉGRADABLES D'UN ÉTHER DE SILYLE CYCLIQUE ET UTILISATIONS ASSOCIÉES
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2020037236A1

  公开（公告）日：2020-02-20

  The present disclosure provides cyclic silyl ethers of the formula (I) and salts thereof. The cyclic silyl ethers may be useful as monomers for preparing polymers. Also described herein are polymers prepared by polymerizing a cyclic silyl ether and optionally one or more additional monomers. The polymers may be degradable (e.g, biodegradable). One or more 0-Si bonds of the polymers may be the degradation sites. Also described herein are compositions and kits including the cyclic silyl ethers or polymers; methods of preparaing the polymers; and methods of using the polymers, compositions, and kits.