2-Amino-1-methyl-2-oxoethyl 3-pyridinecarboxylate | 131222-85-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Amino-1-methyl-2-oxoethyl 3-pyridinecarboxylate
• 英文别名: (1-amino-1-oxopropan-2-yl) pyridine-3-carboxylate
• CAS: 131222-85-0
• 化学式: C₉H₁₀N₂O₃
• mdl: MFCD00870068
• 分子量: 194.19
• InChiKey: GAWYGZGZUXSELI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  82.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Cosmetic composition
  申请人：UNILEVER PLC

  公开号：EP0489581A2

  公开（公告）日：1992-06-10

  Compositions containing an ester of nicotinic acid and a cosmetically acceptable surfactant are provided. These compositions, when applied topically to the human body produce a response such as a sensory or therapeutic response, for example a tingling or warming sensation or an increase in blood flow, which persists after the composition is rinsed from the body. The compositions are particularly suitable for application to the hair and/or scalp where they may encourage hair growth. Compositions for application to the hair and/or scalp preferably additionally comprise hair benefit agents such as hair growth promoters.

  提供含有烟酸酯和化妆品可接受的表面活性剂的组合物。这些组合物在局部涂抹到人体时会产生一种感官或治疗反应，例如刺痛或温热感觉，或者增加血液流动，这种反应在组合物被冲洗后仍然持续。这些组合物特别适用于涂抹到头发和/或头皮，可以促进头发生长。用于涂抹到头发和/或头皮的组合物最好还包括头发益处剂，如促进头发生长的剂。
• TRANSDERMAL VITAMIN B12 DELIVERY PATCH
  申请人：Crawford David

  公开号：US20080160070A1

  公开（公告）日：2008-07-03

  A transdermal vitamin B12 delivery patch is applied to the skin of a user for the delivery of vitamin B12 to the bloodstream of the user. The patch includes a fabric backing and a skin-adhesive polymer matrix that is attached to one side of the fabric backing. The matrix contains a vitamin B12 compound. The vitamin B12 compound diffuses from the matrix through the stratum corneum layer of the user's skin, through the dermis layer of the skin, and into the user's bloodstream.
• [EN] TRANSDERMAL VITAMIN B12 DELIVERY PATCH<br/>[FR] TIMBRE TRANSDERMIQUE D'ADMINISTRATION DE VITAMINE B12
  申请人：NEXAGEN USA LLC

  公开号：WO2008083034A1

  公开（公告）日：2008-07-10

  [EN] A transdermal vitamin B12 delivery patch is applied to the skin of a user for the delivery of vitamin B12 to the bloodstream of the user. The patch includes a fabric backing and a skin-adhesive polymer matrix that is attached to one side of the fabric backing. The matrix contains a vitamin B12 compound. The vitamin B12 compound diffuses from the matrix through the stratum corneum layer of the user's skin, through the dermis layer of the skin, and into the user's bloodstream.
  [FR] L'invention concerne un timbre transdermique d'administration de vitamine B12, qui est appliqué sur la peau d'un utilisateur pour administrer de la vitamine B12 au système sanguin dudit utilisateur. Le timbre comprend une couche support textile et une matrice polymère dermo-adhésive qui est fixée sur une face de la couche support textile. Ladite matrice contient un composé de vitamine B12. Ledit composé de vitamine B12 se transmet à partir de la matrice, à travers la couche cornée de la peau de l'utilisateur, à travers la couche dermique de la peau et jusque dans le système sanguin de l'utilisateur.
• [EN] VITAMIN D3 PHOSPHATE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHODS FOR PREPARING THE COMPOUND<br/>[FR] VITAMINE D3 PHOSPHATE ET SES SELS PHARMACEUTIQUEMENT ACCEPTABLES, COMPOSITIONS PHARMACEUTIQUES COMPRENANT LE COMPOSÉ ET PROCÉDÉS DE PRÉPARATION DU COMPOSÉ
  申请人：[en]KING'S COLLEGE LONDON

  公开号：WO2022084669A1

  公开（公告）日：2022-04-28

  Disclosed is the compound vitamin D3phosphate and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compound and methods for preparing the compound. Also disclosed are methods of treating vitamin D deficiency using the compound. The compound is particularly suitable for transdermal delivery.